The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration

Perminder S. Sachdev, Darren M. Lipnicki, Nicole A. Kochan, John D. Crawford, Anbupalam Thalamuthu, Gavin Andrews, Carol Brayne, Fiona E. Matthews, Blossom C.M. Stephan, Richard B. Lipton, Mindy J. Katz, Karen Ritchie, Isabelle Carrière, Marie Laure Ancelin, Linda C.W. Lam, Candy H.Y. Wong, Ada W.T. Fung, Antonio Guaita, Roberta Vaccaro, Annalisa DavinMary Ganguli, Hiroko Dodge, Tiffany Hughes, Kaarin J. Anstey, Nicolas Cherbuin, Peter Butterworth, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Nicole Schupf, Jennifer Manly, Yaakov Stern, Antonio Lobo, Raùl Lopez-Anton, Javier Santabárbara, Molly Zimmerman, Carol Derby, Grace T.Y. Leung, Wai Chi Chan, Letizia Polito, Simona Abbondanza, Eleonora Valle, Mauro Colombo, Silvia Francesca Vitali, Silvia Fossi, Daniele Zaccaria, Gianluigi Forloni, Simona Villani, Ming X. Tang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

164 Citations (Scopus)


Background Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. Results The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01). Conclusion Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

Original languageEnglish
Article numbere0142388
JournalPLoS ONE
Issue number11
Publication statusPublished - 5 Nov 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this