TY - JOUR
T1 - The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents
AU - Lam, Kim Hung
AU - Gambari, Roberto
AU - Yuen, Marcus Chun Wah
AU - Kan, Chi Wai
AU - Chan, Penni
AU - Xu, Lijin
AU - Tang, Weijun
AU - Chui, Chung Hin
AU - Cheng, Gregory Yin Ming
AU - Wong, Raymond Siu Ming
AU - Lau, Fung Yi
AU - Tong, Cindy Sze Wai
AU - Chan, Andrew Kit Wah
AU - Lai, Paul Bo San
AU - Kok, Stanton Hon Lung
AU - Cheng, Chor Hing
AU - Chan, Albert Sun Chi
AU - Tang, Cheuk On
PY - 2009/4/15
Y1 - 2009/4/15
N2 - A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.
AB - A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.
KW - Antitumor
KW - MDAMB-231 breast cancer
KW - Pyridinyl phosphine oxides
KW - SKHep-1 hepatoma cell lines
UR - https://www.scopus.com/pages/publications/63149168133
U2 - 10.1016/j.bmcl.2009.02.091
DO - 10.1016/j.bmcl.2009.02.091
M3 - Journal article
C2 - 19321340
SN - 0960-894X
VL - 19
SP - 2266
EP - 2269
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 8
ER -
