The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents

Kim Hung Lam; Roberto Gambari; Marcus Chun Wah Yuen; Chi Wai Kan; Penni Chan; Lijin Xu; Weijun Tang; Chung Hin Chui; Gregory Yin Ming Cheng; Raymond Siu Ming Wong; Fung Yi Lau; Cindy Sze Wai Tong; Andrew Kit Wah Chan; Paul Bo San Lai; Stanton Hon Lung Kok; Chor Hing Cheng; Albert Sun Chi Chan; Cheuk On Tang

doi:10.1016/j.bmcl.2009.02.091

The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents

Kim Hung Lam, Roberto Gambari, Marcus Chun Wah Yuen, Chi Wai Kan, Penni Chan, Lijin Xu, Weijun Tang, Chung Hin Chui, Gregory Yin Ming Cheng, Raymond Siu Ming Wong, Fung Yi Lau, Cindy Sze Wai Tong, Andrew Kit Wah Chan, Paul Bo San Lai, Stanton Hon Lung Kok, Chor Hing Cheng, Albert Sun Chi Chan, Cheuk On Tang

Research output: Journal article publication › Journal article › Academic research › peer-review

28 Citations (Scopus)

Abstract

A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.

Original language	English
Pages (from-to)	2266-2269
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.091
Publication status	Published - 15 Apr 2009

Keywords

Antitumor
MDAMB-231 breast cancer
Pyridinyl phosphine oxides
SKHep-1 hepatoma cell lines

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1016/j.bmcl.2009.02.091

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Lam, K. H., Gambari, R., Yuen, M. C. W., Kan, C. W., Chan, P., Xu, L., Tang, W., Chui, C. H., Cheng, G. Y. M., Wong, R. S. M., Lau, F. Y., Tong, C. S. W., Chan, A. K. W., Lai, P. B. S., Kok, S. H. L., Cheng, C. H., Chan, A. S. C., & Tang, C. O. (2009). The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents. Bioorganic and Medicinal Chemistry Letters, 19(8), 2266-2269. https://doi.org/10.1016/j.bmcl.2009.02.091

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title = "The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents",

abstract = "A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.",

keywords = "Antitumor, MDAMB-231 breast cancer, Pyridinyl phosphine oxides, SKHep-1 hepatoma cell lines",

author = "Lam, {Kim Hung} and Roberto Gambari and Yuen, {Marcus Chun Wah} and Kan, {Chi Wai} and Penni Chan and Lijin Xu and Weijun Tang and Chui, {Chung Hin} and Cheng, {Gregory Yin Ming} and Wong, {Raymond Siu Ming} and Lau, {Fung Yi} and Tong, {Cindy Sze Wai} and Chan, {Andrew Kit Wah} and Lai, {Paul Bo San} and Kok, {Stanton Hon Lung} and Cheng, {Chor Hing} and Chan, {Albert Sun Chi} and Tang, {Cheuk On}",

year = "2009",

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doi = "10.1016/j.bmcl.2009.02.091",

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Lam, KH, Gambari, R, Yuen, MCW, Kan, CW, Chan, P, Xu, L, Tang, W, Chui, CH, Cheng, GYM, Wong, RSM, Lau, FY, Tong, CSW, Chan, AKW, Lai, PBS, Kok, SHL, Cheng, CH, Chan, ASC & Tang, CO 2009, 'The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 8, pp. 2266-2269. https://doi.org/10.1016/j.bmcl.2009.02.091

TY - JOUR

T1 - The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents

AU - Lam, Kim Hung

AU - Gambari, Roberto

AU - Yuen, Marcus Chun Wah

AU - Kan, Chi Wai

AU - Chan, Penni

AU - Xu, Lijin

AU - Tang, Weijun

AU - Chui, Chung Hin

AU - Cheng, Gregory Yin Ming

AU - Wong, Raymond Siu Ming

AU - Lau, Fung Yi

AU - Tong, Cindy Sze Wai

AU - Chan, Andrew Kit Wah

AU - Lai, Paul Bo San

AU - Kok, Stanton Hon Lung

AU - Cheng, Chor Hing

AU - Chan, Albert Sun Chi

AU - Tang, Cheuk On

PY - 2009/4/15

Y1 - 2009/4/15

N2 - A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.

AB - A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.

KW - Antitumor

KW - MDAMB-231 breast cancer

KW - Pyridinyl phosphine oxides

KW - SKHep-1 hepatoma cell lines

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DO - 10.1016/j.bmcl.2009.02.091

M3 - Journal article

C2 - 19321340

SN - 0960-894X

VL - 19

SP - 2266

EP - 2269

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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