The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents

Kim Hung Lam, Roberto Gambari, Marcus Chun Wah Yuen, Chi Wai Kan, Penni Chan, Lijin Xu, Weijun Tang, Chung Hin Chui, Gregory Yin Ming Cheng, Raymond Siu Ming Wong, Fung Yi Lau, Cindy Sze Wai Tong, Andrew Kit Wah Chan, Paul Bo San Lai, Stanton Hon Lung Kok, Chor Hing Cheng, Albert Sun Chi Chan, Cheuk On Tang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

28 Citations (Scopus)


A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.
Original languageEnglish
Pages (from-to)2266-2269
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number8
Publication statusPublished - 15 Apr 2009


  • Antitumor
  • MDAMB-231 breast cancer
  • Pyridinyl phosphine oxides
  • SKHep-1 hepatoma cell lines

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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