The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines

Sau Hing Chan, Kim Hung Lam, Chung Hin Chui, Roberto Gambari, Marcus Chun Wah Yuen, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Fung Yi Lau, Yiu Kwok Au, Chor Hing Cheng, Paul Bo Shan Lai, Chi Wai Kan, Stanton Hon Lung Kok, Cheuk On Tang, Albert Sun Chi Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

30 Citations (Scopus)

Abstract

The 'one pot' condensation reaction for the synthesis and potent antiproliferative inhibition of α-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcinoma and SKHep-1 hepatoma cell lines. Preliminary studies showed that the reported bioactivity may be due to the presence of strong electronegative fluorine group at the para-position of the aryl ring.
Original languageEnglish
Pages (from-to)2736-2740
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume44
Issue number6
DOIs
Publication statusPublished - 1 Jun 2009
Externally publishedYes

Keywords

  • α-Phthalimide ketones
  • Anti-tumor activity
  • Breast carcinoma
  • Hepatoma

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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