The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines

Sau Hing Chan; Kim Hung Lam; Chung Hin Chui; Roberto Gambari; Marcus Chun Wah Yuen; Raymond Siu Ming Wong; Gregory Yin Ming Cheng; Fung Yi Lau; Yiu Kwok Au; Chor Hing Cheng; Paul Bo Shan Lai; Chi Wai Kan; Stanton Hon Lung Kok; Cheuk On Tang; Albert Sun Chi Chan

doi:10.1016/j.ejmech.2008.10.024

The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines

Sau Hing Chan, Kim Hung Lam, Chung Hin Chui, Roberto Gambari, Marcus Chun Wah Yuen, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Fung Yi Lau, Yiu Kwok Au, Chor Hing Cheng, Paul Bo Shan Lai, Chi Wai Kan, Stanton Hon Lung Kok, Cheuk On Tang, Albert Sun Chi Chan

Research output: Journal article publication › Journal article › Academic research › peer-review

37 Citations (Scopus)

Abstract

The 'one pot' condensation reaction for the synthesis and potent antiproliferative inhibition of α-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcinoma and SKHep-1 hepatoma cell lines. Preliminary studies showed that the reported bioactivity may be due to the presence of strong electronegative fluorine group at the para-position of the aryl ring.

Original language	English
Pages (from-to)	2736-2740
Number of pages	5
Journal	European Journal of Medicinal Chemistry
Volume	44
Issue number	6
DOIs	https://doi.org/10.1016/j.ejmech.2008.10.024
Publication status	Published - 1 Jun 2009
Externally published	Yes

Keywords

α-Phthalimide ketones
Anti-tumor activity
Breast carcinoma
Hepatoma

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Organic Chemistry

More information

10.1016/j.ejmech.2008.10.024

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Chan, S. H., Lam, K. H., Chui, C. H., Gambari, R., Yuen, M. C. W., Wong, R. S. M., Cheng, G. Y. M., Lau, F. Y., Au, Y. K., Cheng, C. H., Lai, P. B. S., Kan, C. W., Kok, S. H. L., Tang, C. O., & Chan, A. S. C. (2009). The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines. European Journal of Medicinal Chemistry, 44(6), 2736-2740. https://doi.org/10.1016/j.ejmech.2008.10.024

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abstract = "The 'one pot' condensation reaction for the synthesis and potent antiproliferative inhibition of α-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcinoma and SKHep-1 hepatoma cell lines. Preliminary studies showed that the reported bioactivity may be due to the presence of strong electronegative fluorine group at the para-position of the aryl ring.",

keywords = "α-Phthalimide ketones, Anti-tumor activity, Breast carcinoma, Hepatoma",

author = "Chan, {Sau Hing} and Lam, {Kim Hung} and Chui, {Chung Hin} and Roberto Gambari and Yuen, {Marcus Chun Wah} and Wong, {Raymond Siu Ming} and Cheng, {Gregory Yin Ming} and Lau, {Fung Yi} and Au, {Yiu Kwok} and Cheng, {Chor Hing} and Lai, {Paul Bo Shan} and Kan, {Chi Wai} and Kok, {Stanton Hon Lung} and Tang, {Cheuk On} and Chan, {Albert Sun Chi}",

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day = "1",

doi = "10.1016/j.ejmech.2008.10.024",

language = "English",

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Chan, SH, Lam, KH, Chui, CH, Gambari, R, Yuen, MCW, Wong, RSM, Cheng, GYM, Lau, FY, Au, YK, Cheng, CH, Lai, PBS, Kan, CW, Kok, SHL, Tang, CO & Chan, ASC 2009, 'The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines', European Journal of Medicinal Chemistry, vol. 44, no. 6, pp. 2736-2740. https://doi.org/10.1016/j.ejmech.2008.10.024

The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines. / Chan, Sau Hing; Lam, Kim Hung; Chui, Chung Hin et al.
In: European Journal of Medicinal Chemistry, Vol. 44, No. 6, 01.06.2009, p. 2736-2740.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines

AU - Chan, Sau Hing

AU - Lam, Kim Hung

AU - Chui, Chung Hin

AU - Gambari, Roberto

AU - Yuen, Marcus Chun Wah

AU - Wong, Raymond Siu Ming

AU - Cheng, Gregory Yin Ming

AU - Lau, Fung Yi

AU - Au, Yiu Kwok

AU - Cheng, Chor Hing

AU - Lai, Paul Bo Shan

AU - Kan, Chi Wai

AU - Kok, Stanton Hon Lung

AU - Tang, Cheuk On

AU - Chan, Albert Sun Chi

PY - 2009/6/1

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AB - The 'one pot' condensation reaction for the synthesis and potent antiproliferative inhibition of α-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcinoma and SKHep-1 hepatoma cell lines. Preliminary studies showed that the reported bioactivity may be due to the presence of strong electronegative fluorine group at the para-position of the aryl ring.

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KW - Anti-tumor activity

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KW - Hepatoma

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SP - 2736

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JO - European Journal of Medicinal Chemistry

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ER -

The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines

Abstract

Keywords

ASJC Scopus subject areas

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