The potential diagnostic and prognostic role of extracellular vesicles in glioma: current status and future perspectives

Zulfikar Azam, Véronique Quillien, Gang Wang, Shing Shun Tony To

Research output: Journal article publicationReview articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

Lack of appropriate diagnostic/prognostic tools for glioblastoma (GB) is considered one of the major setbacks in the early diagnosis and treatment of this deadly brain tumor. The current gold standard for its diagnosis and staging still relies on invasive biopsy followed by histological examination as well as molecular profiling. Nevertheless, noninvasive approaches are being explored and one example is through the investigation of extracellular vesicles (EVs) in the biofluids of GB patients. EVs are known to carry molecular cargoes such as DNA, mRNA, miRNA, proteins and lipids in almost every type of body fluids. Thus, molecular signature of GB may be present in the EVs derived from these patients. This review focuses on the diagnostic/prognostic potential of EVs in GB, through presenting recent studies on (i) molecular components of EVs, (ii) links between EVs and GB tumor microenvironment, and (iii) clinical potential of EV biomarkers, together with the technical shortcomings researchers need to consider for future studies.

Original languageEnglish
Pages (from-to)353-362
Number of pages10
JournalActa Oncologica
Volume58
Issue number3
Early online date11 Jan 2019
DOIs
Publication statusPublished - Mar 2019

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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