The pivotal role of the dysregulation of cholesterol homeostasis in cancer: Implications for therapeutic targets

Etienne Ho Kit Mok, Terence Kin Wah Lee

Research output: Journal article publicationReview articleAcademic researchpeer-review

11 Citations (Scopus)

Abstract

Cholesterol plays an important role in cellular homeostasis by maintaining the rigidity of cell membranes, providing a medium for signaling transduction, and being converted into other vital macromolecules, such as sterol hormones and bile acids. Epidemiological studies have shown the correlation between cholesterol content and cancer incidence worldwide. Accumulating evidence has shown the emerging roles of the dysregulation of cholesterol metabolism in cancer development. More specifically, recent reports have shown the distinct role of cholesterol in the suppression of immune cells, regulation of cell survival, and modulation of cancer stem cells in cancer. Here, we provide a comprehensive review of the epidemiological analysis, functional roles, and mechanistic action of cholesterol homeostasis in regard to its contribution to cancer development. Based on the existing data, cholesterol homeostasis is identified to be a new key player in cancer pathogenesis. Lastly, we also discuss the therapeutic implications of natural compounds and cholesterol-lowering drugs in cancer prevention and treatment. In conclusion, intervention in cholesterol metabolism may offer a new therapeutic avenue for cancer treatment.

Original languageEnglish
Article number1410
JournalCancers
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Cancer
  • Cancer stem cells
  • Cholesterol esters
  • Cholesterol homeostasis
  • Cholesterol-lowering drugs
  • Immunotherapy
  • Lipoproteins
  • Oxysterols
  • Statins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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