The mitochondrial enzyme pyruvate carboxylase restricts pancreatic β-cell senescence by blocking p53 activation

Keyphrases

• P53 Activation 100%
• Mitochondrial Enzymes 100%
• Cell Senescence 100%
• Pancreatic Cells 100%
• Pyruvate Carboxylase 100%
• Glucose-stimulated Insulin Secretion 50%
• Senescence 40%
• Murine Double Minute 2 (MDM2) 20%
• Aging 10%
• Diabetes 10%
• Cell Proliferation 10%
• Regulatory Effect 10%
• Overexpression 10%
• Mouse Model 10%
• P53-independent 10%
• Cell Cycle Arrest 10%
• High-fat Diet 10%
• Hyperglycemia 10%
• Transcriptome Analysis 10%
• Knockdown 10%
• Binding Motif 10%
• Human Data 10%
• Islet 10%
• Mouse Islets 10%
• Human Islets 10%
• INS-1E Cells 10%
• Chow Diet 10%
• Standard Chow 10%
• Animal Data 10%
• Anaplerotic Flux 10%
• Tricarboxylic Acid 10%
• Physiological Relevance 10%
• Clonal Cell Lines 10%
• Impaired Glucose 10%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• P53 100%
• Pyruvate Carboxylase 100%
• Insulin Release 50%
• Glucose 50%
• Mouse Model 10%
• Gene Expression Profiling 10%
• Cell Proliferation 10%
• Hyperglycemia 10%
• Cell Cycle Arrest 10%
• Cell Cycle Checkpoint 10%