The macaque anterior cingulate cortex translates counterfactual choice value into actual behavioral change

Elsa F. Fouragnan, Bolton K.H. Chau, Davide Folloni, Nils Kolling, Lennart Verhagen, Miriam Klein-Flügge, Lev Tankelevitch, Georgios K. Papageorgiou, Jean Francois Aubry, Jerome Sallet, Matthew F.S. Rushworth

Research output: Journal article publicationJournal articleAcademic researchpeer-review

40 Citations (Scopus)

Abstract

The neural mechanisms mediating sensory-guided decision-making have received considerable attention, but animals often pursue behaviors for which there is currently no sensory evidence. Such behaviors are guided by internal representations of choice values that have to be maintained even when these choices are unavailable. We investigated how four macaque monkeys maintained representations of the value of counterfactual choices—choices that could not be taken at the current moment but which could be taken in the future. Using functional magnetic resonance imaging, we found two different patterns of activity co-varying with values of counterfactual choices in a circuit spanning the hippocampus, the anterior lateral prefrontal cortex and the anterior cingulate cortex. Anterior cingulate cortex activity also reflected whether the internal value representations would be translated into actual behavioral change. To establish the causal importance of the anterior cingulate cortex for this translation process, we used a novel technique, transcranial focused ultrasound stimulation, to reversibly disrupt anterior cingulate cortex activity.

Original languageEnglish
Pages (from-to)797-808
Number of pages12
JournalNature Neuroscience
Volume22
Issue number5
DOIs
Publication statusPublished - 1 May 2019

ASJC Scopus subject areas

  • Neuroscience(all)

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