The lignan-rich fraction from Sambucus Williamsii Hance ameliorates dyslipidemia and insulin resistance and modulates gut microbiota composition in ovariectomized rats

Hui Hui Xiao (Corresponding Author), Lu Lu, Christina Chui Wa Poon, Chi On Chan, Li Jing Wang, Yu Xin Zhu, Li Ping Zhou, Sisi Cao, Wen Xuan Yu, Ka Ying Wong, Daniel Kam Wah Mok, Man Sau Wong (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

Menopausal women are susceptible to have high risk of cardiovascular diseases, type II diabetes and osteoporosis due to the metabolic disorder caused by estrogen deficiency. Accumulating evidence supports that gut microbiota is a key regulator of metabolic diseases. Our previous metabolomics study interestingly demonstrated that the anti-osteoporotic effects of lignan-rich fraction (SWCA) from Sambucus wialliamsii Hance were related to the restoration of a series of lipid and glucose metabolites. This study aims to investigate how SWCA modulates lipid and glucose metabolism and the underlying mechanism. Our results show that oral administration of SWCA (140 mg/kg and 280 mg/kg) for 10 weeks alleviated dyslipidemia, improved liver functions, prevented glucose tolerance and insulin actions, attenuated system inflammation and improved intestinal barrier in OVX rats. It also induced a high abundance of Actinobacteria, and restored microbial composition. We are the first to report the protective effects of the lignan-rich fraction from S. williamsii on dyslipidemia and insulin resistance. Our findings provide strong evidence for the application of this lignan-rich fraction to treat menopausal lipid disorder and insulin resistance-related diseases.

Original languageEnglish
Article number111372
JournalBiomedicine and Pharmacotherapy
Volume137
DOIs
Publication statusPublished - May 2021

Keywords

  • Actinobacteria
  • Dyslipidemia
  • Insulin resistance
  • Lignan-rich fraction
  • Ovariectomized rat
  • Sambucus williamsii Hance

ASJC Scopus subject areas

  • Pharmacology

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