The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong, W. K.Eddie Ip, Gloria Hoi Wan Tso, Man Wai Ng, Wilfred Hing Sang Wong, Ka Wai Helen Law, Raymond W.H. Yung, Eudora Y. Chow, K. L. Au, Eric Y.T. Chan, Wilina Lim, J. S.Malik Peiris, Yu Lung Lau

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Abstract

Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.
Original languageEnglish
Article number82
JournalBMC Infectious Diseases
Volume6
DOIs
Publication statusPublished - 4 May 2006
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases

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