TY - JOUR
T1 - The efficacy of live music for adolescent and young adult patients during hematopoietic stem cell transplantation
AU - Xie, Jianfei
AU - Wan, Ziyu
AU - Duan, Yinglong
AU - Wang, Miao
AU - Luo, Yating
AU - Xiao, Panpan
AU - Kang, Yue
AU - Zhou, Yi
AU - Luo, Xiaofei
AU - Sun, Qian
AU - Cheng, Andy S.K.
N1 - Funding Information:
This research was supported by the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University (NO. YX202006).
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/6/30
Y1 - 2022/6/30
N2 - Background: Music therapy can improve mood in patients undergoing hematopoietic stem cell transplantation (HSCT). However, live music (LM) delivered by professional music therapists is not common in developing countries owing to the shortage of professional music therapists. Thus, in this study, we explored the effects of a multidisciplinary collaborative intervention based on LM on physical and psychological well-being of adolescent and young adult (AYA) patients undergoing HSCT with a quasi-experimental design. Methods: A total of 62 AYA patients agreed to participate and were randomly assigned to the intervention group receiving 4-week LM therapy (n = 31) or control group receiving usual care (n = 31). Depression, salivary cortisol, fatigue, and quality of life were the main outcome indicators measured at baseline, immediately after the intervention, 1 month, and 3 months follow-up. The intervention effects were analyzed by generalized estimating equations. Results: Significant decrease in HADS-D scores occurred in the intervention group compared with wait-list controls at immediately after intervention (p < 0.05). Participants in the LM group had greater improvement in quality of life and lower salivary cortisol level than those in the wait-list control group at immediately, 1 month, and 3 months after intervention (p < 0.05). However, the interaction effects of the BFI scores were not significant. Conclusions: LM therapy significantly alleviated depression and salivary cortisol levels as well as improved quality of life of AYA patients undergoing HSCT.
AB - Background: Music therapy can improve mood in patients undergoing hematopoietic stem cell transplantation (HSCT). However, live music (LM) delivered by professional music therapists is not common in developing countries owing to the shortage of professional music therapists. Thus, in this study, we explored the effects of a multidisciplinary collaborative intervention based on LM on physical and psychological well-being of adolescent and young adult (AYA) patients undergoing HSCT with a quasi-experimental design. Methods: A total of 62 AYA patients agreed to participate and were randomly assigned to the intervention group receiving 4-week LM therapy (n = 31) or control group receiving usual care (n = 31). Depression, salivary cortisol, fatigue, and quality of life were the main outcome indicators measured at baseline, immediately after the intervention, 1 month, and 3 months follow-up. The intervention effects were analyzed by generalized estimating equations. Results: Significant decrease in HADS-D scores occurred in the intervention group compared with wait-list controls at immediately after intervention (p < 0.05). Participants in the LM group had greater improvement in quality of life and lower salivary cortisol level than those in the wait-list control group at immediately, 1 month, and 3 months after intervention (p < 0.05). However, the interaction effects of the BFI scores were not significant. Conclusions: LM therapy significantly alleviated depression and salivary cortisol levels as well as improved quality of life of AYA patients undergoing HSCT.
KW - Depression
KW - Hematopoietic stem cell transplantation
KW - Live music
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=85127239677&partnerID=8YFLogxK
U2 - 10.1007/s00520-022-07001-w
DO - 10.1007/s00520-022-07001-w
M3 - Journal article
C2 - 35347418
AN - SCOPUS:85127239677
SN - 0941-4355
VL - 30
SP - 5789
EP - 5799
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 7
ER -
