The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis

Cheng Xiao; Cheng Lu; Linhua Zhao; Zhenli Liu; Wandong Zhang; Yinghui He; Shilin Chen; Cheuk On Tang; Albert Sun Chi Chan; Aiping Lu

doi:10.1055/s-2006-947240

The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis

Cheng Xiao, Cheng Lu, Linhua Zhao, Zhenli Liu, Wandong Zhang, Yinghui He, Shilin Chen, Cheuk On Tang, Albert Sun Chi Chan, Aiping Lu

Research output: Journal article publication › Journal article › Academic research › peer-review

13 Citations (Scopus)

Abstract

For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer's patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-β in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-β level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer's patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.

Original language	English
Pages (from-to)	1268-1272
Number of pages	5
Journal	Planta Medica
Volume	72
Issue number	14
DOIs	https://doi.org/10.1055/s-2006-947240
Publication status	Published - 1 Nov 2006
Externally published	Yes

Keywords

Collagen-induced arthritis
IEL
LPL
Peyer's patch
Triptolide

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

More information

10.1055/s-2006-947240

Cite this

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title = "The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis",

abstract = "For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer's patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-β in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-β level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer's patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.",

keywords = "Collagen-induced arthritis, IEL, LPL, Peyer's patch, Triptolide",

author = "Cheng Xiao and Cheng Lu and Linhua Zhao and Zhenli Liu and Wandong Zhang and Yinghui He and Shilin Chen and Tang, {Cheuk On} and Chan, {Albert Sun Chi} and Aiping Lu",

year = "2006",

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doi = "10.1055/s-2006-947240",

language = "English",

volume = "72",

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journal = "Planta Medica",

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T1 - The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis

AU - Xiao, Cheng

AU - Lu, Cheng

AU - Zhao, Linhua

AU - Liu, Zhenli

AU - Zhang, Wandong

AU - He, Yinghui

AU - Chen, Shilin

AU - Tang, Cheuk On

AU - Chan, Albert Sun Chi

AU - Lu, Aiping

PY - 2006/11/1

Y1 - 2006/11/1

N2 - For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer's patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-β in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-β level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer's patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.

AB - For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer's patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-β in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-β level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer's patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.

KW - Collagen-induced arthritis

KW - IEL

KW - LPL

KW - Peyer's patch

KW - Triptolide

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DO - 10.1055/s-2006-947240

M3 - Journal article

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SN - 0032-0943

VL - 72

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JO - Planta Medica

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ER -

The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis

Abstract

Keywords

ASJC Scopus subject areas

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