The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis

Cheng Xiao, Cheng Lu, Linhua Zhao, Zhenli Liu, Wandong Zhang, Yinghui He, Shilin Chen, Cheuk On Tang, Albert Sun Chi Chan, Aiping Lu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)

Abstract

For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer's patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-β in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-β level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer's patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.
Original languageEnglish
Pages (from-to)1268-1272
Number of pages5
JournalPlanta Medica
Volume72
Issue number14
DOIs
Publication statusPublished - 1 Nov 2006
Externally publishedYes

Keywords

  • Collagen-induced arthritis
  • IEL
  • LPL
  • Peyer's patch
  • Triptolide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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