The effects of the increasing number of the same chromophore on photosensitization of water-soluble cyclen-based europium complexes with potential for biological applications

Zhenhao Liang, Chi Fai Chan, Yurong Liu, Wing Tak Wong, Chi Sing Lee, Ga Lai Law, Ka Leung Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)

Abstract

Five water-soluble cyclen-based europium complexes incorporated with the pendant chelating chromophore, 2-methyl-4-(2-(4-propoxyphenyl)ethynyl)pyridine (L), as the antenna in different ratios have been synthesized and full structural characterization, photophysical measurement and in vitro biological studies were carried out. The antenna-to-metal ratios were 4 (Eu-4L), 3 (Eu-3L), 2 (1,4-disubstituted Eu-o-2L and 1,7-disubstituted Eu-p-2L) and 1 (Eu-1L). It was found that the definitive distinction between Eu-o-2L and Eu-p-2L could be interpreted from the emission spectra of Eu3+ at room and low temperatures. With all the results from subcellular stability testing (via titrations), in vitro imaging, cytotoxicity assays and cellular uptake profiles, Eu-4L with an overall +3 charge demonstrated subcellular localization towards lysosomes and was a potential compound for a selective time-resolved bio-labelling probe. This journal is
Original languageEnglish
Pages (from-to)13347-13356
Number of pages10
JournalRSC Advances
Volume5
Issue number18
DOIs
Publication statusPublished - 1 Jan 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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