The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors

Chi Fai Chan; Chen Xie; Ming Kiu Tsang; Sam Lear; Lixiong Dai; Yan Zhou; Jakub Cicho; Miroslaw Karbowiak; Dariusz Hreniak; Rongfeng Lan; Steve L. Cobb; Michael Hon Wah Lam; Jianhua Hao; Ka Leung Wong

doi:10.1002/ejic.201500321

The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors

Chi Fai Chan, Chen Xie, Ming Kiu Tsang, Sam Lear, Lixiong Dai, Yan Zhou, Jakub Cicho, Miroslaw Karbowiak, Dariusz Hreniak, Rongfeng Lan, Steve L. Cobb, Michael Hon Wah Lam, Jianhua Hao, Ka Leung Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

9 Citations (Scopus)

Abstract

KGaA, Weinheim. In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF₄@SiO₂-P₁ nanoparticles achieve the best performance for in vitro imaging, G2 phase cell arrest, and, hence, cell cycle inhibition.

Original language	English
Pages (from-to)	4539-4545
Number of pages	7
Journal	European Journal of Inorganic Chemistry
Volume	2015
Issue number	27
DOIs	https://doi.org/10.1002/ejic.201500321
Publication status	Published - 1 Sept 2015

Keywords

Antitumor agents
Imaging agents
Inhibitors
Lanthanides
Medicinal chemistry
Nanoparticles
Peptides

ASJC Scopus subject areas

Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1002/ejic.201500321

Cite this

Chan, C. F., Xie, C., Tsang, M. K., Lear, S., Dai, L., Zhou, Y., Cicho, J., Karbowiak, M., Hreniak, D., Lan, R., Cobb, S. L., Lam, M. H. W., Hao, J., & Wong, K. L. (2015). The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors. European Journal of Inorganic Chemistry, 2015(27), 4539-4545. https://doi.org/10.1002/ejic.201500321

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title = "The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors",

abstract = "KGaA, Weinheim. In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF4@SiO2-P1 nanoparticles achieve the best performance for in vitro imaging, G2 phase cell arrest, and, hence, cell cycle inhibition.",

keywords = "Antitumor agents, Imaging agents, Inhibitors, Lanthanides, Medicinal chemistry, Nanoparticles, Peptides",

author = "Chan, {Chi Fai} and Chen Xie and Tsang, {Ming Kiu} and Sam Lear and Lixiong Dai and Yan Zhou and Jakub Cicho and Miroslaw Karbowiak and Dariusz Hreniak and Rongfeng Lan and Cobb, {Steve L.} and Lam, {Michael Hon Wah} and Jianhua Hao and Wong, {Ka Leung}",

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month = sep,

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doi = "10.1002/ejic.201500321",

language = "English",

volume = "2015",

pages = "4539--4545",

journal = "European Journal of Inorganic Chemistry",

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Chan, CF, Xie, C, Tsang, MK, Lear, S, Dai, L, Zhou, Y, Cicho, J, Karbowiak, M, Hreniak, D, Lan, R, Cobb, SL, Lam, MHW, Hao, J & Wong, KL 2015, 'The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors', European Journal of Inorganic Chemistry, vol. 2015, no. 27, pp. 4539-4545. https://doi.org/10.1002/ejic.201500321

The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors. / Chan, Chi Fai; Xie, Chen; Tsang, Ming Kiu et al.
In: European Journal of Inorganic Chemistry, Vol. 2015, No. 27, 01.09.2015, p. 4539-4545.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors

AU - Chan, Chi Fai

AU - Xie, Chen

AU - Tsang, Ming Kiu

AU - Lear, Sam

AU - Dai, Lixiong

AU - Zhou, Yan

AU - Cicho, Jakub

AU - Karbowiak, Miroslaw

AU - Hreniak, Dariusz

AU - Lan, Rongfeng

AU - Cobb, Steve L.

AU - Lam, Michael Hon Wah

AU - Hao, Jianhua

AU - Wong, Ka Leung

PY - 2015/9/1

Y1 - 2015/9/1

N2 - KGaA, Weinheim. In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF4@SiO2-P1 nanoparticles achieve the best performance for in vitro imaging, G2 phase cell arrest, and, hence, cell cycle inhibition.

AB - KGaA, Weinheim. In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF4@SiO2-P1 nanoparticles achieve the best performance for in vitro imaging, G2 phase cell arrest, and, hence, cell cycle inhibition.

KW - Antitumor agents

KW - Imaging agents

KW - Inhibitors

KW - Lanthanides

KW - Medicinal chemistry

KW - Nanoparticles

KW - Peptides

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U2 - 10.1002/ejic.201500321

DO - 10.1002/ejic.201500321

M3 - Journal article

SN - 1434-1948

VL - 2015

SP - 4539

EP - 4545

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 27

ER -

The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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