TY - JOUR
T1 - The effects of major depressive disorder on the sequential organization of information processing stages
T2 - An event-related potential study
AU - Ahorsu, Daniel Kwasi
AU - Chung, Ken
AU - Wong, Ho Hon
AU - Yiu, Michael Gar Chung
AU - Mok, Yat Fung
AU - Lei, Ka Shun
AU - Tsang, Hector Wing Hong
N1 - Funding Information:
Funding: This research was funded by The Hong Kong Polytechnic University as part of Daniel Kwasi Ahorsu’s PhD studentship associated money under the supervision of Hector Tsang. For the remaining authors none were declared and the APC was funded by Hector Tsang.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/12/4
Y1 - 2020/12/4
N2 - The adverse effects of depression on patients’ life have been reported but information about its effects on the sequential organization of the information processing stages remains poorly understood as previous studies focused only on distinct stages. This study adds to existing knowledge by examining the effect of major depressive disorder (MDD) on the sequential organization of information processing, executive and community functioning. Fifty-seven participants with 19 participants each for first episode depression (FMDD), recurrent episodes depression (RMDD), and healthy controls (HCs) participated in this study. They completed assessments on executive and community functioning measures, and choice reaction time task (CRTT) for the event-related potential (ERP) data. Findings revealed no significant between-group difference in executive functioning but participants with depression (FMDD and RMDD) were found to be more depressed, with FMDD participants having worse community functioning skills compared with HCs. There was no significant between-group main effect on behavioral data. ERP data showed significantly less positive-going P3b among RMDD participants compared with HCs. FMDD participants used a different information processing strategy at P1, while HCs and RMDD participants used a different processing strategy at N2b compared with the other group(s), respectively. The results suggest the use of multifaceted assessment to get a holistic view of the health status of people with MDD in order to inform clinicians on the appropriate interventional strategies needed for the patient.
AB - The adverse effects of depression on patients’ life have been reported but information about its effects on the sequential organization of the information processing stages remains poorly understood as previous studies focused only on distinct stages. This study adds to existing knowledge by examining the effect of major depressive disorder (MDD) on the sequential organization of information processing, executive and community functioning. Fifty-seven participants with 19 participants each for first episode depression (FMDD), recurrent episodes depression (RMDD), and healthy controls (HCs) participated in this study. They completed assessments on executive and community functioning measures, and choice reaction time task (CRTT) for the event-related potential (ERP) data. Findings revealed no significant between-group difference in executive functioning but participants with depression (FMDD and RMDD) were found to be more depressed, with FMDD participants having worse community functioning skills compared with HCs. There was no significant between-group main effect on behavioral data. ERP data showed significantly less positive-going P3b among RMDD participants compared with HCs. FMDD participants used a different information processing strategy at P1, while HCs and RMDD participants used a different processing strategy at N2b compared with the other group(s), respectively. The results suggest the use of multifaceted assessment to get a holistic view of the health status of people with MDD in order to inform clinicians on the appropriate interventional strategies needed for the patient.
KW - Choice reaction time task
KW - Cognitive-energetical linear stage model
KW - Community function
KW - Event-related potential
KW - Executive function
KW - Information processing
KW - Linear model
KW - Major depressive disorder
KW - Parallel model
UR - http://www.scopus.com/inward/record.url?scp=85097150185&partnerID=8YFLogxK
U2 - 10.3390/brainsci10120935
DO - 10.3390/brainsci10120935
M3 - Journal article
AN - SCOPUS:85097150185
VL - 10
SP - 1
EP - 18
JO - Brain Sciences
JF - Brain Sciences
SN - 2076-3425
IS - 12
M1 - 935
ER -