TY - JOUR
T1 - The effects of hippocampal and fimbria-fornix lesions on prepulse inhibition
AU - Pouzet, Bruno
AU - Feldon, Joram
AU - Veenman, C. Leo
AU - Richmond, Mark
AU - Rawlins, J. Nicholas P.
AU - Yee, Kay Yan Benjamin
AU - Weiner, Ina
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The present experiments tested the effects of conventional (dorsal aspiration and electrolytic) and excitotoxic (N-methyl-D-aspartate [NMDA]) hippocampal lesions and fimbria-fornix (FF) transection on prepulse inhibition (PPI) of startle response and on open-field activity. Activity was increased by FF transection and by conventional but not excitotoxic hippocampal lesions; complete NMDA lesion increased amphetamine-induced activity. Whereas dorsal hippocampal aspiration lesion disrupted PPI, the phenomenon was not affected by dorsal hippocampal electrolytic lesion, partial or complete excitotoxic (NMDA) hippocampal lesions, or complete FF transection, which interrupted the cholinergic input to the hippocampus as well as the hippocampal-subicular input to the nucleus accumbens. Systemic apomorphine disrupted PPI in both FF-transected rats and their controls. It is suggested that the hippocampus is essential for PPI disruption rather than for PPI expression.
AB - The present experiments tested the effects of conventional (dorsal aspiration and electrolytic) and excitotoxic (N-methyl-D-aspartate [NMDA]) hippocampal lesions and fimbria-fornix (FF) transection on prepulse inhibition (PPI) of startle response and on open-field activity. Activity was increased by FF transection and by conventional but not excitotoxic hippocampal lesions; complete NMDA lesion increased amphetamine-induced activity. Whereas dorsal hippocampal aspiration lesion disrupted PPI, the phenomenon was not affected by dorsal hippocampal electrolytic lesion, partial or complete excitotoxic (NMDA) hippocampal lesions, or complete FF transection, which interrupted the cholinergic input to the hippocampus as well as the hippocampal-subicular input to the nucleus accumbens. Systemic apomorphine disrupted PPI in both FF-transected rats and their controls. It is suggested that the hippocampus is essential for PPI disruption rather than for PPI expression.
UR - http://www.scopus.com/inward/record.url?scp=0033507875&partnerID=8YFLogxK
U2 - 10.1037/0735-7044.113.5.968
DO - 10.1037/0735-7044.113.5.968
M3 - Journal article
C2 - 10571479
SN - 0735-7044
VL - 113
SP - 968
EP - 981
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 5
ER -