The effects of a lifestyle intervention program on physical outcomes, depression, and quality of life in adults with metabolic syndrome: A randomized clinical trial

Qun Wang, Sek Ying Chair, Mi Ling Eliza Wong

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25 Citations (Scopus)


� 2016 Elsevier Ireland Ltd Background/objectives Lifestyle modification is recommended as the primary intervention for metabolic syndrome (MetS). The study was to examine the effects of a lifestyle intervention program (LIP) on physical outcomes, depression, and quality of life (QoL) in Chinese adults with MetS. Methods A randomized control trial design was used. A three-month LIP guided by the Health Promotion Model was developed, including a lifestyle modification booklet, one session of discharge education, and six telephone follow-ups. Patients with MetS were recruited from the inpatient departments of a hospital and were randomized to receive either the LIP or usual care. The physical outcomes, depression (Depression subscale of Hospital Anxiety and Depression Scale), and QoL (Medical Outcome Study Short Form-12, SF-12) were measured at baseline, one-month (T1) and three-month (T2). The effects of the LIP were examined by the generalized estimating equation (GEE) model. Results The study recruited 173 participants, with 86 in the intervention group and 87 in the control. Continuous improvements were observed in all the study outcomes in the intervention group. The GEE model revealed significant improvements in body weight (T1: p�=�0.017, T2: p�=�0.007), body mass index (T1: p�=�0.015, T2: p�=�0.009), depression (T1: p�=�0.027, T2: p�<�0.001), and physical aspects of QoL at T2 (p�=�0.02). Conclusions The current LIP was effective in losing body weight, improving depression and QoL of MetS populations in three-month observation. Considering its low-cost and convenience, the LIP could be applied in clinical practice to improve patient outcomes.
Original languageEnglish
Pages (from-to)461-467
Number of pages7
JournalInternational Journal of Cardiology
Publication statusPublished - 1 Mar 2017
Externally publishedYes


  • Body weight
  • Depression
  • Lifestyle intervention
  • Metabolic syndrome
  • Quality of life

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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