The effect of simultaneous dual-focus integration on the global flash multifocal electroretinogram in the human eye

Mavis M.Y. Fung; Kai Yip Choi; Henry H.L. Chan

doi:10.1111/opo.12751

The effect of simultaneous dual-focus integration on the global flash multifocal electroretinogram in the human eye

Mavis M.Y. Fung, Kai Yip Choi, Henry H.L. Chan

Research output: Journal article publication › Journal article › Academic research › peer-review

13 Citations (Scopus)

Abstract

Purpose: To investigate the effect of simultaneous dual-focus (DF) on retinal activities measured by global flash multifocal electroretinogram (mfERG). Methods: Thirty adults were recruited for mfERG measurement under three conditions: in-focus (i.e., no defocus), +2.50 D DF and +7.50 D DF, administered using single vision contact lenses and DF lenses. The direct component (DC) and the induced component (IC) of the mfERG were pooled into central macular (0–8°), para-macular (8–18°) and peri-macular (18–30°) regions, and then compared across the three conditions using two-way, repeated measures ANOVA. Results: Simultaneous DF had a significant effect on the IC amplitude, which was significantly stronger under +7.50 D DF (p < 0.01) than for the in-focus condition, which was mostly derived from the central and para-macular regions. No significant effect was observed for the +2.50 D DF condition. Conclusion: Under the effect of relatively strong simultaneous DF integration, the retina showed an enhanced retinal response, which originated from the inner retina. Compared with the peri-macular region, central and para-macular responses appeared to be enhanced.

Original language	English
Pages (from-to)	171-178
Number of pages	8
Journal	Ophthalmic and Physiological Optics
Volume	41
Issue number	1
Early online date	29 Oct 2020
DOIs	https://doi.org/10.1111/opo.12751
Publication status	Published - Jan 2021

Keywords

contact lenses
electrophysiology
Myopia
retina

ASJC Scopus subject areas

Ophthalmology
Optometry
Sensory Systems

More information

10.1111/opo.12751

http://hdl.handle.net/10397/92684

Cite this

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title = "The effect of simultaneous dual-focus integration on the global flash multifocal electroretinogram in the human eye",

abstract = "Purpose: To investigate the effect of simultaneous dual-focus (DF) on retinal activities measured by global flash multifocal electroretinogram (mfERG). Methods: Thirty adults were recruited for mfERG measurement under three conditions: in-focus (i.e., no defocus), +2.50 D DF and +7.50 D DF, administered using single vision contact lenses and DF lenses. The direct component (DC) and the induced component (IC) of the mfERG were pooled into central macular (0–8°), para-macular (8–18°) and peri-macular (18–30°) regions, and then compared across the three conditions using two-way, repeated measures ANOVA. Results: Simultaneous DF had a significant effect on the IC amplitude, which was significantly stronger under +7.50 D DF (p < 0.01) than for the in-focus condition, which was mostly derived from the central and para-macular regions. No significant effect was observed for the +2.50 D DF condition. Conclusion: Under the effect of relatively strong simultaneous DF integration, the retina showed an enhanced retinal response, which originated from the inner retina. Compared with the peri-macular region, central and para-macular responses appeared to be enhanced.",

keywords = "contact lenses, electrophysiology, Myopia, retina",

author = "Fung, {Mavis M.Y.} and Choi, {Kai Yip} and Chan, {Henry H.L.}",

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year = "2021",

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AU - Choi, Kai Yip

AU - Chan, Henry H.L.

N1 - Funding Information: This study was supported by a General Research Fund from the Research Grants Council of the Hong Kong Special Administrative Region, China (PolyU 151001/17M) and Internal Research Grants, The Hong Kong Polytechnic University (Z0GF). Publisher Copyright: © 2020 The Authors Ophthalmic and Physiological Optics © 2020 The College of Optometrists Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021/1

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N2 - Purpose: To investigate the effect of simultaneous dual-focus (DF) on retinal activities measured by global flash multifocal electroretinogram (mfERG). Methods: Thirty adults were recruited for mfERG measurement under three conditions: in-focus (i.e., no defocus), +2.50 D DF and +7.50 D DF, administered using single vision contact lenses and DF lenses. The direct component (DC) and the induced component (IC) of the mfERG were pooled into central macular (0–8°), para-macular (8–18°) and peri-macular (18–30°) regions, and then compared across the three conditions using two-way, repeated measures ANOVA. Results: Simultaneous DF had a significant effect on the IC amplitude, which was significantly stronger under +7.50 D DF (p < 0.01) than for the in-focus condition, which was mostly derived from the central and para-macular regions. No significant effect was observed for the +2.50 D DF condition. Conclusion: Under the effect of relatively strong simultaneous DF integration, the retina showed an enhanced retinal response, which originated from the inner retina. Compared with the peri-macular region, central and para-macular responses appeared to be enhanced.

AB - Purpose: To investigate the effect of simultaneous dual-focus (DF) on retinal activities measured by global flash multifocal electroretinogram (mfERG). Methods: Thirty adults were recruited for mfERG measurement under three conditions: in-focus (i.e., no defocus), +2.50 D DF and +7.50 D DF, administered using single vision contact lenses and DF lenses. The direct component (DC) and the induced component (IC) of the mfERG were pooled into central macular (0–8°), para-macular (8–18°) and peri-macular (18–30°) regions, and then compared across the three conditions using two-way, repeated measures ANOVA. Results: Simultaneous DF had a significant effect on the IC amplitude, which was significantly stronger under +7.50 D DF (p < 0.01) than for the in-focus condition, which was mostly derived from the central and para-macular regions. No significant effect was observed for the +2.50 D DF condition. Conclusion: Under the effect of relatively strong simultaneous DF integration, the retina showed an enhanced retinal response, which originated from the inner retina. Compared with the peri-macular region, central and para-macular responses appeared to be enhanced.

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The effect of simultaneous dual-focus integration on the global flash multifocal electroretinogram in the human eye

Abstract

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ASJC Scopus subject areas

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