The effect of simultaneous dual-focus integration on the global flash multifocal electroretinogram in the human eye

Mavis M.Y. Fung, Kai Yip Choi, Henry H.L. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)


Purpose: To investigate the effect of simultaneous dual-focus (DF) on retinal activities measured by global flash multifocal electroretinogram (mfERG). Methods: Thirty adults were recruited for mfERG measurement under three conditions: in-focus (i.e., no defocus), +2.50 D DF and +7.50 D DF, administered using single vision contact lenses and DF lenses. The direct component (DC) and the induced component (IC) of the mfERG were pooled into central macular (0–8°), para-macular (8–18°) and peri-macular (18–30°) regions, and then compared across the three conditions using two-way, repeated measures ANOVA. Results: Simultaneous DF had a significant effect on the IC amplitude, which was significantly stronger under +7.50 D DF (p < 0.01) than for the in-focus condition, which was mostly derived from the central and para-macular regions. No significant effect was observed for the +2.50 D DF condition. Conclusion: Under the effect of relatively strong simultaneous DF integration, the retina showed an enhanced retinal response, which originated from the inner retina. Compared with the peri-macular region, central and para-macular responses appeared to be enhanced.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalOphthalmic and Physiological Optics
Issue number1
Early online date29 Oct 2020
Publication statusPublished - Jan 2021


  • contact lenses
  • electrophysiology
  • Myopia
  • retina

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry
  • Sensory Systems

Cite this