The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): The Pan European Emesis Registry (PEER)

M. Aapro, Alexandros Molasiotis, M. Dicato, I. Peláez, Á Rodríguez-Lescure, D. Pastorelli, L. Ma, T. Burke, A. Gu, P. Gascon, F. Roila

Research output: Journal article publicationJournal articleAcademic researchpeer-review

205 Citations (Scopus)

Abstract

Background: While guidelines for preventing chemotherapy-induced nausea and vomiting (CINV) are widely available, clinical uptake of guidelines remains low. Our objective was to evaluate the effect of guideline-consistent CINV prophylaxis (GCCP) on patient outcomes. Patients and methods: This prospective, observational multicenter study enrolled chemotherapy-naive adults initiating single-day highly or moderately emetogenic chemotherapy (HEC or MEC) for cancer. Patients completed 6-day daily diaries beginning with cycle 1 for up to three chemotherapy cycles. The primary study end point, complete response (no emesis and no use of rescue therapy) during 120 h after cycle 1 chemotherapy, was compared between GCCP and guideline-inconsistent CINV prophylaxis (GICP) cohorts using multivariate logistic regression, adjusting for potential confounding factors. Results: In cycle 1 (N = 991), use of GCCP was 55% and 46% during acute and delayed phases, respectively, and 29% for the overall study period (acute plus delayed phases). Complete response was recorded by 172/287 (59.9%) and 357/704 (50.7%) patients in GCCP and GICP cohorts, respectively (P = 0.008). The adjusted odds ratio for complete response was 1.43 (95% confidence interval 1.04-1.97; P = 0.027) for patients receiving GCCP versus GICP. Conclusion: GCCP reduces the incidence of CINV after single-day HEC and MEC.
Original languageEnglish
Article numbermds021
Pages (from-to)1986-1992
Number of pages7
JournalAnnals of Oncology
Volume23
Issue number8
DOIs
Publication statusPublished - 1 Aug 2012
Externally publishedYes

Keywords

  • Antiemetic therapy
  • Chemotherapy
  • Emesis
  • Guidelines
  • Nausea

ASJC Scopus subject areas

  • Hematology
  • Oncology

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