The effect of divalent metal ions on the thermostability of c3

Shea Ping Yip, W. H.P. Lewis

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)


Thermostability studies on human complement component C3 showed that saturation of the electronegative sites in the C3 molecule with divalent cations offered some protection against heat denaturation, a finding not previously reported in the literature. To inactivate C3 in about 30 minutes, the required temperature was 61°C in the presence of excess Ca2+ions, 59.5°C in the presence of excess of Mg2+ions, but only 54°C in the absence of these ionized metal ions.
Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalImmunological Investigations
Issue number4
Publication statusPublished - 1 Jan 1992

ASJC Scopus subject areas

  • Immunology

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