The characteristics of multifocal electroretinogram in isolated perfused porcine eye: Cellular contributions to the in vitro porcine mfERG

Yiu Fai Ng; Ho Lung Henry Chan; Chi Ho To; Keng Hung Maurice Yap

doi:10.1007/s10633-008-9124-y

The characteristics of multifocal electroretinogram in isolated perfused porcine eye: Cellular contributions to the in vitro porcine mfERG

Yiu Fai Ng, Ho Lung Henry Chan, Chi Ho To, Keng Hung Maurice Yap

Research output: Journal article publication › Journal article › Academic research › peer-review

5 Citations (Scopus)

Abstract

We investigated characteristics of multifocal electroretinograms (mfERG) from in vitro perfused porcine eyes. TTX, NMDA, APB, and PDA were used to identify contributions to the mfERG from inner retinal neurons, ON-pathway, OFF-pathway, and photoreceptors. The cellular contributions of the first-order kernel (K1) in an isolated perfused porcine mfERG came from both inner and outer retina, and were similar to those of in vivo porcine mfERG. In addition, application of isoflurane and propofol caused interference with the mfERG response which resembled inner retinal activities sensitive to TTX + NMDA application. Improved understanding of the cellular origins of the perfused porcine mfERG, in the absence of anesthetic agents, is useful for identifying changes shown in the waveform under anesthesia.

Original language	English
Pages (from-to)	205-214
Number of pages	10
Journal	Documenta Ophthalmologica
Volume	117
Issue number	3
DOIs	https://doi.org/10.1007/s10633-008-9124-y
Publication status	Published - 1 Nov 2008

Keywords

Anesthesia
Multifocal electroretinography
Pig
Retina

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Physiology (medical)

More information

10.1007/s10633-008-9124-y

Cite this

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abstract = "We investigated characteristics of multifocal electroretinograms (mfERG) from in vitro perfused porcine eyes. TTX, NMDA, APB, and PDA were used to identify contributions to the mfERG from inner retinal neurons, ON-pathway, OFF-pathway, and photoreceptors. The cellular contributions of the first-order kernel (K1) in an isolated perfused porcine mfERG came from both inner and outer retina, and were similar to those of in vivo porcine mfERG. In addition, application of isoflurane and propofol caused interference with the mfERG response which resembled inner retinal activities sensitive to TTX + NMDA application. Improved understanding of the cellular origins of the perfused porcine mfERG, in the absence of anesthetic agents, is useful for identifying changes shown in the waveform under anesthesia.",

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The characteristics of multifocal electroretinogram in isolated perfused porcine eye: Cellular contributions to the in vitro porcine mfERG

Abstract

Keywords

ASJC Scopus subject areas

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