TY - JOUR
T1 - The Causes and Consequences of miR-503 Dysregulation and Its Impact on Cardiovascular Disease and Cancer
AU - He, Yanjing
AU - Cai, Yin
AU - Pai, Pearl Mingchu
AU - Ren, Xinling
AU - Xia, Zhengyuan
N1 - Funding Information:
This work is supported by the General Research Fund (17158616), and Health and Medical Research Fund (05161826).
Publisher Copyright:
© Copyright © 2021 He, Cai, Pai, Ren and Xia.
PY - 2021/3/8
Y1 - 2021/3/8
N2 - microRNAs (miRs) are short, non-coding RNAs that regulate gene expression by mRNA degradation or translational repression. Accumulated studies have demonstrated that miRs participate in various biological processes including cell differentiation, proliferation, apoptosis, metabolism and development, and the dysregulation of miRs expression are involved in different human diseases, such as neurological, cardiovascular disease and cancer. microRNA-503 (miR-503), one member of miR-16 family, has been studied widely in cardiovascular disease and cancer. In this review, we summarize and discuss the studies of miR-503 in vitro and in vivo, and how miR-503 regulates gene expression from different aspects of pathological processes of diseases, including carcinogenesis, angiogenesis, tissue fibrosis and oxidative stress; We will also discuss the mechanisms of dysregulation of miR-503, and whether miR-503 could be applied as a diagnostic marker or therapeutic target in cardiovascular disease or cancer.
AB - microRNAs (miRs) are short, non-coding RNAs that regulate gene expression by mRNA degradation or translational repression. Accumulated studies have demonstrated that miRs participate in various biological processes including cell differentiation, proliferation, apoptosis, metabolism and development, and the dysregulation of miRs expression are involved in different human diseases, such as neurological, cardiovascular disease and cancer. microRNA-503 (miR-503), one member of miR-16 family, has been studied widely in cardiovascular disease and cancer. In this review, we summarize and discuss the studies of miR-503 in vitro and in vivo, and how miR-503 regulates gene expression from different aspects of pathological processes of diseases, including carcinogenesis, angiogenesis, tissue fibrosis and oxidative stress; We will also discuss the mechanisms of dysregulation of miR-503, and whether miR-503 could be applied as a diagnostic marker or therapeutic target in cardiovascular disease or cancer.
KW - angiogenesis
KW - cancer
KW - cardiovascular disease
KW - microRNA-503
KW - microRNAs
KW - oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85102946083&partnerID=8YFLogxK
U2 - 10.3389/fphar.2021.629611
DO - 10.3389/fphar.2021.629611
M3 - Review article
AN - SCOPUS:85102946083
SN - 1663-9812
VL - 12
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 629611
ER -
