The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle

Keyphrases

• Skeletal muscle 100%
• Adaptor Protein 100%
• Glucose-stimulated Insulin Secretion 100%
• APPL2 100%
• TBC1D1 100%
• Insulin 55%
• Plasma Membrane 33%
• Phosphorylation 33%
• Glucose Transporter 4 (GLUT4) 33%
• Glucose Uptake 33%
• Threonine 22%
• Myotubes 22%
• APPL1 22%
• Membrane Recruitment 22%
• Suppression Effect 11%
• Overexpression 11%
• Physiological Function 11%
• Type 2 Diabetes Mellitus (T2DM) 11%
• Glucose Metabolism 11%
• Hyperglycemia 11%
• Muscle Cells 11%
• Knockdown 11%
• Akt Activation 11%
• Interaction Partner 11%
• Insulin Action 11%
• Insulin Sensitivity 11%
• BAR Domain 11%
• Enhanced Interaction 11%
• Insulin Independence 11%
• GLUT4 Translocation 11%
• Glucose Tolerance 11%
• Conditional Deletion 11%
• Rab GTPase-activating Protein 11%
• Muscle Impairment 11%

Medicine and Dentistry

• Glucose Uptake 100%
• Adaptor Protein 100%
• Skeletal Muscle 100%
• Glucose Transporter 4 80%
• Cell Membrane 60%
• Serine 40%
• Threonine 40%
• Myotube 40%
• Maturity Onset Diabetes of the Young 20%
• Hyperglycemia 20%
• Alanine 20%
• Guanosine Triphosphatase Activating Protein 20%
• Insulin Sensitivity 20%
• Glucose Metabolism 20%
• Glucose Tolerance 20%
• Rab Protein 20%
• Protein Kinase B 20%

Biochemistry, Genetics and Molecular Biology

• Glucose Transport 100%
• Skeletal Muscle 100%
• GLUT4 80%
• Cell Membrane 60%
• APPL1 40%
• Serine 40%
• Threonine 40%
• GTPase-activating Protein 20%
• BAR Domain 20%
• Glucose Metabolism 20%
• Insulin Sensitivity 20%
• Hyperglycemia 20%
• Alanine 20%
• Protein Kinase B 20%