TGF-β1 Signaling: Immune Dynamics of Chronic Kidney Diseases

Philip Chiu Tsun Tang, Siu Wing Chan, Cai-bin Zhang, Cristina Alexandra García Córdoba, Ying-ying Zhang, Ka Fai To, Kam Tong Leung, Hui-yao Lan, Ming Kuen Patrick Tang

Research output: Journal article publicationReview articleAcademic researchpeer-review

13 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide, imposing a great burden on the healthcare system. Regrettably, effective CKD therapeutic strategies are yet available due to their elusive pathogenic mechanisms. CKD is featured by progressive inflammation and fibrosis associated with immune cell dysfunction, leading to the formation of an inflammatory microenvironment, which ultimately exacerbating renal fibrosis. Transforming growth factor β1 (TGF-β1) is an indispensable immunoregulator promoting CKD progression by controlling the activation, proliferation, and apoptosis of immunocytes via both canonical and non-canonical pathways. More importantly, recent studies have uncovered a new mechanism of TGF-β1 for de novo generation of myofibroblast via macrophage-myofibroblast transition (MMT). This review will update the versatile roles of TGF-β signaling in the dynamics of renal immunity, a better understanding may facilitate the discovery of novel therapeutic strategies against CKD.

Original languageEnglish
Article number628519
JournalFrontiers in Medicine
Volume8
DOIs
Publication statusPublished - 25 Feb 2021

Keywords

  • chronic kidney disease
  • immunity
  • kidney fibrosis
  • renal inflammation
  • transforming growth factor β

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'TGF-β1 Signaling: Immune Dynamics of Chronic Kidney Diseases'. Together they form a unique fingerprint.

Cite this