TY - JOUR
T1 - TGF-β1 Signaling
T2 - Immune Dynamics of Chronic Kidney Diseases
AU - Tang, Philip Chiu Tsun
AU - Chan, Siu Wing
AU - Zhang, Cai-bin
AU - Córdoba, Cristina Alexandra García
AU - Zhang, Ying-ying
AU - To, Ka Fai
AU - Leung, Kam Tong
AU - Lan, Hui-yao
AU - Tang, Ming Kuen Patrick
N1 - Funding Information:
This study was supported by Research Grants Council of Hong Kong (14106518, 14111019, 14111720); The Chinese University of Hong Kong’s Faculty Innovation Award (4620528) and Direct Grant for Research (4054510).
Publisher Copyright:
© Copyright © 2021 Tang, Chan, Zhang, García Córdoba, Zhang, To, Leung, Lan and Tang.
PY - 2021/2/25
Y1 - 2021/2/25
N2 - Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide, imposing a great burden on the healthcare system. Regrettably, effective CKD therapeutic strategies are yet available due to their elusive pathogenic mechanisms. CKD is featured by progressive inflammation and fibrosis associated with immune cell dysfunction, leading to the formation of an inflammatory microenvironment, which ultimately exacerbating renal fibrosis. Transforming growth factor β1 (TGF-β1) is an indispensable immunoregulator promoting CKD progression by controlling the activation, proliferation, and apoptosis of immunocytes via both canonical and non-canonical pathways. More importantly, recent studies have uncovered a new mechanism of TGF-β1 for de novo generation of myofibroblast via macrophage-myofibroblast transition (MMT). This review will update the versatile roles of TGF-β signaling in the dynamics of renal immunity, a better understanding may facilitate the discovery of novel therapeutic strategies against CKD.
AB - Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide, imposing a great burden on the healthcare system. Regrettably, effective CKD therapeutic strategies are yet available due to their elusive pathogenic mechanisms. CKD is featured by progressive inflammation and fibrosis associated with immune cell dysfunction, leading to the formation of an inflammatory microenvironment, which ultimately exacerbating renal fibrosis. Transforming growth factor β1 (TGF-β1) is an indispensable immunoregulator promoting CKD progression by controlling the activation, proliferation, and apoptosis of immunocytes via both canonical and non-canonical pathways. More importantly, recent studies have uncovered a new mechanism of TGF-β1 for de novo generation of myofibroblast via macrophage-myofibroblast transition (MMT). This review will update the versatile roles of TGF-β signaling in the dynamics of renal immunity, a better understanding may facilitate the discovery of novel therapeutic strategies against CKD.
KW - chronic kidney disease
KW - immunity
KW - kidney fibrosis
KW - renal inflammation
KW - transforming growth factor β
UR - http://www.scopus.com/inward/record.url?scp=85102459514&partnerID=8YFLogxK
U2 - 10.3389/fmed.2021.628519
DO - 10.3389/fmed.2021.628519
M3 - Review article
SN - 2296-858X
VL - 8
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 628519
ER -