TY - JOUR
T1 - Tenascin C in Lung Diseases
AU - Donovan, Chantal
AU - Bai, Xu
AU - Chan, Yik Lung
AU - Feng, Min
AU - Ho, Kin-Fai
AU - Guo, Hai
AU - Chen, Hui
AU - Oliver, Brian G.
N1 - Funding Information:
This research was supported by a project grant National Health & Medical Research Council (NHMRC) Australia APP1158186. Y.L.C. was supported by a Peter Doherty Fellowship by NHMRC Australia. K.F.H. is supported by grants from the Research Grant Council of The Hong Kong Special Administrative Region China, Project No. CUHK 14212116. H.G. is supported by RGC of the Hong Kong Special Administrative Region, CRF/C5004-15E, the Strategic Focus Area scheme of The Research Institute for Sustainable Urban Development at The Hong Kong Polytechnic University, 1-BBW9.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/2
Y1 - 2023/2
N2 - Tenascin C (TNC) is a multifunctional large extracellular matrix protein involved in numerous cellular processes in embryonic development and can be increased in disease, or under conditions of trauma or cell stress in adults. However, the role of TNC in lung diseases remains unclear. In this study, we investigated the expression of TNC during development, in offspring following maternal particulate matter (PM) exposure, asthma, chronic obstructive pulmonary disease (COPD) and lung cancer. TNC expression is increased during lung development in biopsy cells, endothelial cells, mesenchymal cells, and epithelial cells. Maternal PM exposure increased TNC and collagen deposition, which was not affected by the removal of PM exposure after pregnancy. TNC expression was also increased in basal epithelial cells and fibroblasts in patients with asthma and AT2 and endothelial cells in patients with COPD. Furthermore, there was an increase in the expression of TNC in stage II compared to stage IA lung cancer; however, overall survival analysis showed no correlation between levels of TNC and survival. In conclusion, TNC is increased during lung development, in offspring following maternal PM exposure, and in asthma, COPD, and lung cancer tissues. Therefore, targeting TNC may provide a novel therapeutic target for lung diseases.
AB - Tenascin C (TNC) is a multifunctional large extracellular matrix protein involved in numerous cellular processes in embryonic development and can be increased in disease, or under conditions of trauma or cell stress in adults. However, the role of TNC in lung diseases remains unclear. In this study, we investigated the expression of TNC during development, in offspring following maternal particulate matter (PM) exposure, asthma, chronic obstructive pulmonary disease (COPD) and lung cancer. TNC expression is increased during lung development in biopsy cells, endothelial cells, mesenchymal cells, and epithelial cells. Maternal PM exposure increased TNC and collagen deposition, which was not affected by the removal of PM exposure after pregnancy. TNC expression was also increased in basal epithelial cells and fibroblasts in patients with asthma and AT2 and endothelial cells in patients with COPD. Furthermore, there was an increase in the expression of TNC in stage II compared to stage IA lung cancer; however, overall survival analysis showed no correlation between levels of TNC and survival. In conclusion, TNC is increased during lung development, in offspring following maternal PM exposure, and in asthma, COPD, and lung cancer tissues. Therefore, targeting TNC may provide a novel therapeutic target for lung diseases.
KW - COPD
KW - asthma
KW - foetal programming
KW - lung cancer
KW - lung development
KW - particular matter
UR - http://www.scopus.com/inward/record.url?scp=85148949401&partnerID=8YFLogxK
U2 - 10.3390/biology12020199
DO - 10.3390/biology12020199
M3 - Journal article
SN - 2079-7737
VL - 12
JO - Biology
JF - Biology
IS - 2
M1 - 199
ER -