Targeting strategies on miRNA-21 and PDCD4 for glioblastoma

Gang Wang, Jun Jie Wang, Hong Ming Tang, Shing Shun Tony To

Research output: Journal article publicationReview articleAcademic researchpeer-review

34 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are often deregulated in glioblastoma multiforme (GBM). Downregulation of microRNA-21 (miR-21), especially in GBM, is responsible for increased apoptosis, decreased cell proliferation and invasion, increased G0/G1 cell cycle arrest, and reduced chemotherapeutic resistance to doxorubicin. Furthermore, it is a critical regulator of multiple downstream genes and signaling pathways involved in gliomagenesis. Programmed cell death 4 (PDCD4) is critical in mediating apoptosis in GBM, and is downregulated by miR-21, which may mediate the resistance of glioblastoma cells against chemotherapy or radiation via its target genes PDCD4. Evidence is mounting that how alterations of these miRNAs transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the roles of miRNAs family members (particularly miR-21 and its target gene PDCD4) in tumors like glioblastoma and new targeting strategies, as examples some new targeting therapeutic methods and molecular mechanisms of signal pathways in glioblastoma therapeutics, to give the reader the current trends of approach to target regulation of these miRNA and genes for future glioma therapies.
Original languageEnglish
Pages (from-to)64-74
Number of pages11
JournalArchives of Biochemistry and Biophysics
Volume580
DOIs
Publication statusPublished - 13 Jul 2015

Keywords

  • Apoptosis
  • Glioblastoma
  • miRNA
  • Oncogenes
  • Resistance
  • Signaling pathways

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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