Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound

Zhihai Qiu; Shashwati Kala; Jinghui Guo; Quanxiang Xian; Jiejun Zhu; Ting Zhu; Xuandi Hou; Kin Fung Wong; Minyi Yang; Haoru Wang; Lei Sun

doi:10.1016/j.celrep.2020.108033

Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound

Zhihai Qiu
, Shashwati Kala
, Jinghui Guo
, Quanxiang Xian
, Jiejun Zhu
, Ting Zhu
, Xuandi Hou
, Kin Fung Wong
, Minyi Yang
, Haoru Wang
, Lei Sun

Research output: Journal article publication › Journal article › Academic research › peer-review

94 Citations (Scopus)

Abstract

Qiu et al. demonstrate a targeted sonogenetic approach: sensitizing neurons to low-intensity ultrasound stimulation by expressing the mechanosensitive channel MscL-G22S in vitro and in vivo. Ultrasound triggered Ca²⁺ influx-consequent neuronal activation in MscL-expressing cells. Transcranially stimulating MscL-expressing brain regions evoked muscular responses and c-Fos expression without widespread non-specific activation.

Original language	English
Article number	108033
Journal	Cell Reports
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2020.108033
Publication status	Published - 18 Aug 2020

Keywords

mechanosensitive ion channel
MscL-G22S
noninvasive neuromodulation
targeted neurostimulation
transcranial ultrasound stimulation

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

More information

10.1016/j.celrep.2020.108033

http://hdl.handle.net/10397/88121

Cite this

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title = "Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound",

abstract = "Qiu et al. demonstrate a targeted sonogenetic approach: sensitizing neurons to low-intensity ultrasound stimulation by expressing the mechanosensitive channel MscL-G22S in vitro and in vivo. Ultrasound triggered Ca2+ influx-consequent neuronal activation in MscL-expressing cells. Transcranially stimulating MscL-expressing brain regions evoked muscular responses and c-Fos expression without widespread non-specific activation.",

keywords = "mechanosensitive ion channel, MscL-G22S, noninvasive neuromodulation, targeted neurostimulation, transcranial ultrasound stimulation",

author = "Zhihai Qiu and Shashwati Kala and Jinghui Guo and Quanxiang Xian and Jiejun Zhu and Ting Zhu and Xuandi Hou and Wong, \{Kin Fung\} and Minyi Yang and Haoru Wang and Lei Sun",

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doi = "10.1016/j.celrep.2020.108033",

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AU - Qiu, Zhihai

AU - Kala, Shashwati

AU - Guo, Jinghui

AU - Xian, Quanxiang

AU - Zhu, Jiejun

AU - Zhu, Ting

AU - Hou, Xuandi

AU - Wong, Kin Fung

AU - Yang, Minyi

AU - Wang, Haoru

AU - Sun, Lei

PY - 2020/8/18

Y1 - 2020/8/18

N2 - Qiu et al. demonstrate a targeted sonogenetic approach: sensitizing neurons to low-intensity ultrasound stimulation by expressing the mechanosensitive channel MscL-G22S in vitro and in vivo. Ultrasound triggered Ca2+ influx-consequent neuronal activation in MscL-expressing cells. Transcranially stimulating MscL-expressing brain regions evoked muscular responses and c-Fos expression without widespread non-specific activation.

AB - Qiu et al. demonstrate a targeted sonogenetic approach: sensitizing neurons to low-intensity ultrasound stimulation by expressing the mechanosensitive channel MscL-G22S in vitro and in vivo. Ultrasound triggered Ca2+ influx-consequent neuronal activation in MscL-expressing cells. Transcranially stimulating MscL-expressing brain regions evoked muscular responses and c-Fos expression without widespread non-specific activation.

KW - mechanosensitive ion channel

KW - MscL-G22S

KW - noninvasive neuromodulation

KW - targeted neurostimulation

KW - transcranial ultrasound stimulation

UR - https://www.scopus.com/pages/publications/85089466315

U2 - 10.1016/j.celrep.2020.108033

DO - 10.1016/j.celrep.2020.108033

M3 - Journal article

C2 - 32814040

AN - SCOPUS:85089466315

SN - 2211-1247

VL - 32

JO - Cell Reports

JF - Cell Reports

IS - 7

M1 - 108033

ER -

Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound

Abstract

Keywords

ASJC Scopus subject areas

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