Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound

Zhihai Qiu, Shashwati Kala, Jinghui Guo, Quanxiang Xian, Jiejun Zhu, Ting Zhu, Xuandi Hou, Kin Fung Wong, Minyi Yang, Haoru Wang, Lei Sun

Research output: Journal article publicationJournal articleAcademic researchpeer-review

8 Citations (Scopus)

Abstract

Qiu et al. demonstrate a targeted sonogenetic approach: sensitizing neurons to low-intensity ultrasound stimulation by expressing the mechanosensitive channel MscL-G22S in vitro and in vivo. Ultrasound triggered Ca2+ influx-consequent neuronal activation in MscL-expressing cells. Transcranially stimulating MscL-expressing brain regions evoked muscular responses and c-Fos expression without widespread non-specific activation.

Original languageEnglish
Article number108033
JournalCell Reports
Volume32
Issue number7
DOIs
Publication statusPublished - 18 Aug 2020

Keywords

  • mechanosensitive ion channel
  • MscL-G22S
  • noninvasive neuromodulation
  • targeted neurostimulation
  • transcranial ultrasound stimulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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