Abstract
Qiu et al. demonstrate a targeted sonogenetic approach: sensitizing neurons to low-intensity ultrasound stimulation by expressing the mechanosensitive channel MscL-G22S in vitro and in vivo. Ultrasound triggered Ca2+ influx-consequent neuronal activation in MscL-expressing cells. Transcranially stimulating MscL-expressing brain regions evoked muscular responses and c-Fos expression without widespread non-specific activation.
Original language | English |
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Article number | 108033 |
Journal | Cell Reports |
Volume | 32 |
Issue number | 7 |
DOIs | |
Publication status | Published - 18 Aug 2020 |
Keywords
- mechanosensitive ion channel
- MscL-G22S
- noninvasive neuromodulation
- targeted neurostimulation
- transcranial ultrasound stimulation
ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology