TY - JOUR
T1 - Tannic acid/Mg2+-based versatile coating to manipulate the osteoimmunomodulation of implants
AU - He, Min
AU - Gao, Xinhui
AU - Fan, Yadi
AU - Xie, Li
AU - Yang, Mo
AU - Tian, Weidong
N1 - Funding Information:
This study was supported by the National Key Research and Development Program of China (Grant no. 2017YFA0104800), Science and technology innovation talent program of Sichuan Province (Grant no. 20CXRC0070), National Natural Science Foundation of China (NSFC) (Grant No. 31771077), the General Research Fund of Hong Kong Research Grants Council (Grant No: 15210818) and the internal funds of the Hong Kong Polytechnic University (Grant No.:1-ZE1E and G-YW4B).
Publisher Copyright:
© The Royal Society of Chemistry 2021.
PY - 2021/1/28
Y1 - 2021/1/28
N2 - Instead of directly stimulating osteogenesis, endowing an implant surface with a favourable osteoimmunomodulatory (OIM) function has emerged as a new effective strategy to enhance osteointegration. Though metal-phenolic coatings have demonstrated to possess an immunomodulatory function, their potential application in manipulating an osteoimmune response has not been well explored. Herein, in order to develop a simple, rapid and universal coating method to impart excellent OIM to hard tissue implants, tannic acid (TA) and Mg2+were selected to form a coating on Ti plate based on metal-phenolic chemistry. Besides its virtues of simplicity, ultrafastness, low-cost, and versatility, another merit for the coating method is that it can easily combine the unique functions of metal ions and phenolic ligands. The chelated Mg2+can not only activate macrophage polarization towards the anti-inflammatory phenotype but also directly stimulate the osteogenic differentiation of bone marrow-derived stem cells (BMSCs). TA motifs rendered the coating with an excellent reactive oxygen species (ROS) scavenging capacity. TA and Mg2+showed synergistic effects on regulating macrophage biological behaviour, suppressing its polarization towards the M1 phenotype, and promoting its polarization towards the M2 phenotype.In vivohistological analysis also demonstrated that the TA/Mg2+coating could effectively inhibit the host response. Finally, the formed osteoimmune environment obviously enhanced the osteogenic differentiation of BMSCs. The above results demonstrated that the designed TA/Mg2+coating not only possessed the function of directly stimulating osteogenesis but also the function of manipulating OIM to a desired one. Hence, it has great potential to be applied on advanced hard tissue implants to enhance osteointegration.
AB - Instead of directly stimulating osteogenesis, endowing an implant surface with a favourable osteoimmunomodulatory (OIM) function has emerged as a new effective strategy to enhance osteointegration. Though metal-phenolic coatings have demonstrated to possess an immunomodulatory function, their potential application in manipulating an osteoimmune response has not been well explored. Herein, in order to develop a simple, rapid and universal coating method to impart excellent OIM to hard tissue implants, tannic acid (TA) and Mg2+were selected to form a coating on Ti plate based on metal-phenolic chemistry. Besides its virtues of simplicity, ultrafastness, low-cost, and versatility, another merit for the coating method is that it can easily combine the unique functions of metal ions and phenolic ligands. The chelated Mg2+can not only activate macrophage polarization towards the anti-inflammatory phenotype but also directly stimulate the osteogenic differentiation of bone marrow-derived stem cells (BMSCs). TA motifs rendered the coating with an excellent reactive oxygen species (ROS) scavenging capacity. TA and Mg2+showed synergistic effects on regulating macrophage biological behaviour, suppressing its polarization towards the M1 phenotype, and promoting its polarization towards the M2 phenotype.In vivohistological analysis also demonstrated that the TA/Mg2+coating could effectively inhibit the host response. Finally, the formed osteoimmune environment obviously enhanced the osteogenic differentiation of BMSCs. The above results demonstrated that the designed TA/Mg2+coating not only possessed the function of directly stimulating osteogenesis but also the function of manipulating OIM to a desired one. Hence, it has great potential to be applied on advanced hard tissue implants to enhance osteointegration.
UR - http://www.scopus.com/inward/record.url?scp=85100450657&partnerID=8YFLogxK
U2 - 10.1039/d0tb01577f
DO - 10.1039/d0tb01577f
M3 - Journal article
C2 - 33427278
AN - SCOPUS:85100450657
SN - 2050-7518
VL - 9
SP - 1096
EP - 1106
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 4
ER -