Tackling Aging by Using miRNA as a Target and a Tool

Wing Fu Lai, Marie Lin, Wing Tak Wong

Research output: Journal article publicationReview articleAcademic researchpeer-review

8 Citations (Scopus)

Abstract

miRNA is a class of short noncoding RNA that regulates gene expression at the post-transcriptional level. Evidence of age-associated changes in miRNA expression has been collected in models ranging from nematodes to humans; however, there has been little discussion of how to turn our knowledge of miRNA biology into antiaging therapy. This opinion article provides a snapshot of our current understanding of the roles of miRNA in modulating the aging process. We discuss major chemical techniques for modifying the miRNA structure as well as developing delivery systems for intervention. Finally, technical needs to be met for bench-to-clinic translation of miRNA-based interventions are highlighted for future research.

Original languageEnglish
Pages (from-to)673-684
Number of pages12
JournalTrends in Molecular Medicine
Volume25
Issue number8
DOIs
Publication statusPublished - Aug 2019

Keywords

  • aging
  • cellular senescence
  • gene delivery
  • genetic manipulation
  • miRNA

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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