Synthesis of zwitterionic acrylamide copolymers for biocompatible applications

Huanhuan Ren, Zhankui Mei, Yangyang Chen, Shaojun Chen, Zaochuan Ge, Jinlian Hu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)


In order to prepare acrylamide copolymers with non-toxicity for environment-friendly materials, a series of zwitterionic acrylamide copolymers with varying acrylamide content were synthesized with DMAPS (3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) and acrylamide via free radical polymerization. The structural properties and cytotoxicity are carefully investigated. The results demonstrate that DMAPS-co-acrylamide copolymers contain DMAPS and acrylamide segments that form a matrix consisting of strong electrostatic interactions as well as strong hydrogen bonding. DMAPS segments exhibit negligible influence on the glass phase transition behavior, yet affect the composite’s water-contact angle. The optimum hydrophilic properties are obtained by adjusting the acrylamide content to 50 wt%. All DMAPS-co-acrylamide copolymers are measured to be non-toxic. The DMAPS segments allow for suitable contribution to the biocompatibility of the synthesized copolymer, in which copolymers containing higher DMAPS content demonstrate better biocompatibility.
Original languageEnglish
Pages (from-to)3-16
Number of pages14
JournalJournal of Bioactive and Compatible Polymers
Issue number1
Publication statusPublished - 1 Jan 2018


  • acrylamide
  • biocompatibility
  • electrostatic
  • non-toxicity
  • Zwitterionic polymer

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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