Synthesis of Yolk-Shell Polymeric Nanocapsules Encapsulated with Monodispersed Upconversion Nanoparticle for Dual-Responsive Controlled Drug Release

Xiaotao Wang; Xiaoping Liu; Li Wang; Chak Yin Tang; Wing Cheung Law; Gaowen Zhang; Yonggui Liao; Chuang Liu; Zuifang Liu

doi:10.1021/acs.macromol.8b01770

Synthesis of Yolk-Shell Polymeric Nanocapsules Encapsulated with Monodispersed Upconversion Nanoparticle for Dual-Responsive Controlled Drug Release

Xiaotao Wang, Xiaoping Liu, Li Wang, Chak Yin Tang, Wing Cheung Law, Gaowen Zhang, Yonggui Liao, Chuang Liu, Zuifang Liu

Research output: Journal article publication › Journal article › Academic research › peer-review

27 Citations (Scopus)

Abstract

Dual-responsive (light and pH) yolk-shell structured drug delivery nanocapsules, each consisting of a movable upconversion nanoparticle (UCNP) core and a shrinkable poly(methacrylic acid) (PMAA) shell, were prepared by distillation precipitation polymerization. Monodispersed NaYF₄: Yb³⁺/Tm³⁺ UCNPs were synthesized and encapsulated in silica templates, followed by coating to form PMAA shells. Subsequently, the silica templates were dissolved to form nanocavities for drug loading. The PMAA shell contains pH and ultraviolet (UV) light sensing moieties, enabling a control release upon the exposure of nanocapsules to these stimuli. The near-infrared (NIR)-to-UV feature of UCNPs allows azobenzene isomerization to be light triggered remotely to control contraction and swelling of PMAA shells. The loading efficiency of the anticancer drug doxorubicin (DXR) was up to 17 wt % due to the unique nanoporous structure of PMAA shells. The values of the diffusion coefficient under different release conditions were determined using the Baker-Lonsdale model to facilitate the design of dual-responsive drug release devices or systems.

Original language	English
Pages (from-to)	10074-10082
Number of pages	9
Journal	Macromolecules
Volume	51
Issue number	24
DOIs	https://doi.org/10.1021/acs.macromol.8b01770
Publication status	Published - 26 Dec 2018

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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10.1021/acs.macromol.8b01770

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title = "Synthesis of Yolk-Shell Polymeric Nanocapsules Encapsulated with Monodispersed Upconversion Nanoparticle for Dual-Responsive Controlled Drug Release",

abstract = "Dual-responsive (light and pH) yolk-shell structured drug delivery nanocapsules, each consisting of a movable upconversion nanoparticle (UCNP) core and a shrinkable poly(methacrylic acid) (PMAA) shell, were prepared by distillation precipitation polymerization. Monodispersed NaYF4: Yb3+/Tm3+ UCNPs were synthesized and encapsulated in silica templates, followed by coating to form PMAA shells. Subsequently, the silica templates were dissolved to form nanocavities for drug loading. The PMAA shell contains pH and ultraviolet (UV) light sensing moieties, enabling a control release upon the exposure of nanocapsules to these stimuli. The near-infrared (NIR)-to-UV feature of UCNPs allows azobenzene isomerization to be light triggered remotely to control contraction and swelling of PMAA shells. The loading efficiency of the anticancer drug doxorubicin (DXR) was up to 17 wt % due to the unique nanoporous structure of PMAA shells. The values of the diffusion coefficient under different release conditions were determined using the Baker-Lonsdale model to facilitate the design of dual-responsive drug release devices or systems.",

author = "Xiaotao Wang and Xiaoping Liu and Li Wang and Tang, {Chak Yin} and Law, {Wing Cheung} and Gaowen Zhang and Yonggui Liao and Chuang Liu and Zuifang Liu",

year = "2018",

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AU - Wang, Xiaotao

AU - Liu, Xiaoping

AU - Wang, Li

AU - Tang, Chak Yin

AU - Law, Wing Cheung

AU - Zhang, Gaowen

AU - Liao, Yonggui

AU - Liu, Chuang

AU - Liu, Zuifang

PY - 2018/12/26

Y1 - 2018/12/26

N2 - Dual-responsive (light and pH) yolk-shell structured drug delivery nanocapsules, each consisting of a movable upconversion nanoparticle (UCNP) core and a shrinkable poly(methacrylic acid) (PMAA) shell, were prepared by distillation precipitation polymerization. Monodispersed NaYF4: Yb3+/Tm3+ UCNPs were synthesized and encapsulated in silica templates, followed by coating to form PMAA shells. Subsequently, the silica templates were dissolved to form nanocavities for drug loading. The PMAA shell contains pH and ultraviolet (UV) light sensing moieties, enabling a control release upon the exposure of nanocapsules to these stimuli. The near-infrared (NIR)-to-UV feature of UCNPs allows azobenzene isomerization to be light triggered remotely to control contraction and swelling of PMAA shells. The loading efficiency of the anticancer drug doxorubicin (DXR) was up to 17 wt % due to the unique nanoporous structure of PMAA shells. The values of the diffusion coefficient under different release conditions were determined using the Baker-Lonsdale model to facilitate the design of dual-responsive drug release devices or systems.

AB - Dual-responsive (light and pH) yolk-shell structured drug delivery nanocapsules, each consisting of a movable upconversion nanoparticle (UCNP) core and a shrinkable poly(methacrylic acid) (PMAA) shell, were prepared by distillation precipitation polymerization. Monodispersed NaYF4: Yb3+/Tm3+ UCNPs were synthesized and encapsulated in silica templates, followed by coating to form PMAA shells. Subsequently, the silica templates were dissolved to form nanocavities for drug loading. The PMAA shell contains pH and ultraviolet (UV) light sensing moieties, enabling a control release upon the exposure of nanocapsules to these stimuli. The near-infrared (NIR)-to-UV feature of UCNPs allows azobenzene isomerization to be light triggered remotely to control contraction and swelling of PMAA shells. The loading efficiency of the anticancer drug doxorubicin (DXR) was up to 17 wt % due to the unique nanoporous structure of PMAA shells. The values of the diffusion coefficient under different release conditions were determined using the Baker-Lonsdale model to facilitate the design of dual-responsive drug release devices or systems.

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Synthesis of Yolk-Shell Polymeric Nanocapsules Encapsulated with Monodispersed Upconversion Nanoparticle for Dual-Responsive Controlled Drug Release

Abstract

ASJC Scopus subject areas

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