Synthesis of Yolk-Shell Polymeric Nanocapsules Encapsulated with Monodispersed Upconversion Nanoparticle for Dual-Responsive Controlled Drug Release

Xiaotao Wang, Xiaoping Liu, Li Wang, Chak Yin Tang, Wing Cheung Law, Gaowen Zhang, Yonggui Liao, Chuang Liu, Zuifang Liu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

21 Citations (Scopus)


Dual-responsive (light and pH) yolk-shell structured drug delivery nanocapsules, each consisting of a movable upconversion nanoparticle (UCNP) core and a shrinkable poly(methacrylic acid) (PMAA) shell, were prepared by distillation precipitation polymerization. Monodispersed NaYF4: Yb3+/Tm3+ UCNPs were synthesized and encapsulated in silica templates, followed by coating to form PMAA shells. Subsequently, the silica templates were dissolved to form nanocavities for drug loading. The PMAA shell contains pH and ultraviolet (UV) light sensing moieties, enabling a control release upon the exposure of nanocapsules to these stimuli. The near-infrared (NIR)-to-UV feature of UCNPs allows azobenzene isomerization to be light triggered remotely to control contraction and swelling of PMAA shells. The loading efficiency of the anticancer drug doxorubicin (DXR) was up to 17 wt % due to the unique nanoporous structure of PMAA shells. The values of the diffusion coefficient under different release conditions were determined using the Baker-Lonsdale model to facilitate the design of dual-responsive drug release devices or systems.

Original languageEnglish
Pages (from-to)10074-10082
Number of pages9
Issue number24
Publication statusPublished - 26 Dec 2018

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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