Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

Lixiong Dai; Junhui Zhang; Yuqing Chen; Lewis E. Mackenzie; Robert Pal; Ga Lai Law

doi:10.1021/acs.inorgchem.9b01799

Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

Lixiong Dai
, Junhui Zhang
, Yuqing Chen
, Lewis E. Mackenzie
, Robert Pal
, Ga Lai Law

Research output: Journal article publication › Journal article › Academic research › peer-review

29 Citations (Scopus)

Abstract

One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]^5- exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (g_lum) values of 0.285 (δJ = 1) for [TbL3]^- and 0.241 (δJ = 1) for [TbL4]^5- in buffer solutions were recorded.

Original language	English
Pages (from-to)	12506-12510
Number of pages	5
Journal	Inorganic Chemistry
Volume	58
Issue number	19
DOIs	https://doi.org/10.1021/acs.inorgchem.9b01799
Publication status	Published - 7 Oct 2019

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

More information

10.1021/acs.inorgchem.9b01799

http://hdl.handle.net/10397/101510

Cite this

@article{b09cb8396c404c99893cc8403fd8f43e,

title = "Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence",

abstract = "One-step cyclization of a tetraazamacrocycle 5 with 70\% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93\% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5- exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (δJ = 1) for [TbL3]- and 0.241 (δJ = 1) for [TbL4]5- in buffer solutions were recorded.",

author = "Lixiong Dai and Junhui Zhang and Yuqing Chen and Mackenzie, \{Lewis E.\} and Robert Pal and Law, \{Ga Lai\}",

year = "2019",

month = oct,

day = "7",

doi = "10.1021/acs.inorgchem.9b01799",

language = "English",

volume = "58",

pages = "12506--12510",

journal = "Inorganic Chemistry",

issn = "0020-1669",

publisher = "American Chemical Society",

number = "19",

}

Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence. / Dai, Lixiong; Zhang, Junhui; Chen, Yuqing et al.
In: Inorganic Chemistry, Vol. 58, No. 19, 07.10.2019, p. 12506-12510.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

AU - Dai, Lixiong

AU - Zhang, Junhui

AU - Chen, Yuqing

AU - Mackenzie, Lewis E.

AU - Pal, Robert

AU - Law, Ga Lai

PY - 2019/10/7

Y1 - 2019/10/7

N2 - One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5- exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (δJ = 1) for [TbL3]- and 0.241 (δJ = 1) for [TbL4]5- in buffer solutions were recorded.

AB - One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5- exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (δJ = 1) for [TbL3]- and 0.241 (δJ = 1) for [TbL4]5- in buffer solutions were recorded.

UR - https://www.scopus.com/pages/publications/85072630912

U2 - 10.1021/acs.inorgchem.9b01799

DO - 10.1021/acs.inorgchem.9b01799

M3 - Journal article

C2 - 31490674

AN - SCOPUS:85072630912

SN - 0020-1669

VL - 58

SP - 12506

EP - 12510

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 19

ER -

Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

Abstract

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