Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

Lixiong Dai; Junhui Zhang; Yuqing Chen; Lewis E. Mackenzie; Robert Pal; Ga Lai Law

doi:10.1021/acs.inorgchem.9b01799

Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

Lixiong Dai, Junhui Zhang, Yuqing Chen, Lewis E. Mackenzie, Robert Pal, Ga Lai Law

Research output: Journal article publication › Journal article › Academic research › peer-review

26 Citations (Scopus)

Abstract

One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]^5- exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (g_lum) values of 0.285 (δJ = 1) for [TbL3]^- and 0.241 (δJ = 1) for [TbL4]^5- in buffer solutions were recorded.

Original language	English
Pages (from-to)	12506-12510
Number of pages	5
Journal	Inorganic Chemistry
Volume	58
Issue number	19
DOIs	https://doi.org/10.1021/acs.inorgchem.9b01799
Publication status	Published - 7 Oct 2019

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

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10.1021/acs.inorgchem.9b01799

http://hdl.handle.net/10397/101510

Cite this

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title = "Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence",

abstract = "One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5- exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (δJ = 1) for [TbL3]- and 0.241 (δJ = 1) for [TbL4]5- in buffer solutions were recorded.",

author = "Lixiong Dai and Junhui Zhang and Yuqing Chen and Mackenzie, {Lewis E.} and Robert Pal and Law, {Ga Lai}",

year = "2019",

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language = "English",

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journal = "Inorganic Chemistry",

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Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence. / Dai, Lixiong; Zhang, Junhui; Chen, Yuqing et al.
In: Inorganic Chemistry, Vol. 58, No. 19, 07.10.2019, p. 12506-12510.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

AU - Dai, Lixiong

AU - Zhang, Junhui

AU - Chen, Yuqing

AU - Mackenzie, Lewis E.

AU - Pal, Robert

AU - Law, Ga Lai

PY - 2019/10/7

Y1 - 2019/10/7

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AB - One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5- exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (δJ = 1) for [TbL3]- and 0.241 (δJ = 1) for [TbL4]5- in buffer solutions were recorded.

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U2 - 10.1021/acs.inorgchem.9b01799

DO - 10.1021/acs.inorgchem.9b01799

M3 - Journal article

C2 - 31490674

AN - SCOPUS:85072630912

SN - 0020-1669

VL - 58

SP - 12506

EP - 12510

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 19

ER -

Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

Abstract

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