Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

Lixiong Dai, Junhui Zhang, Yuqing Chen, Lewis E. Mackenzie, Robert Pal, Ga Lai Law

Research output: Journal article publicationJournal articleAcademic researchpeer-review

12 Citations (Scopus)

Abstract

One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5- exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (δJ = 1) for [TbL3]- and 0.241 (δJ = 1) for [TbL4]5- in buffer solutions were recorded.

Original languageEnglish
Pages (from-to)12506-12510
Number of pages5
JournalInorganic Chemistry
Volume58
Issue number19
DOIs
Publication statusPublished - 7 Oct 2019

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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