Synthesis of silver-incorporated hydroxyapatite nanocomposites for antimicrobial implant coatings

Xiangmei Liu, Yanan Mou, Shuilin Wu, Hau Chung Man

Research output: Journal article publicationJournal articleAcademic researchpeer-review

83 Citations (Scopus)


Because of excellent osteoconductivity and resorbability, hydroxyapatite (HA) is commonly used as a bone substitute material or implant coating. Both ionic and metallic silver are considered to have a broad spectrum of antimicrobial properties especially associated with biomaterial-related infections. The present work proposes a facile chemical reduction method to synthesize an Ag incorporated HA nanocomposite. Ammoniacal silver solution was firstly prepared and then added into the HA solution, followed by hydrazine hydrate (N2H4·H2O) being used to reduce the silver ions to metallic silver. The formed Ag nanoparticles had diameters of 20-30 nm and were firmly attached on the HA particle surfaces. This approach can also keep the integrity of the HA chemical structure and the morphology. The strain Escherichia coli was used to evaluate the antibacterial effect of the nanocomposite. An In vitro bacterial adhesion study indicated a significant enhancement in the antibacterial property of silver containing HA.
Original languageEnglish
Pages (from-to)748-757
Number of pages10
JournalApplied Surface Science
Publication statusPublished - 15 May 2013


  • Antibacterial
  • Hydroxyapatite
  • Implant
  • Nanocomposite
  • Silver

ASJC Scopus subject areas

  • Surfaces, Coatings and Films


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