Synthesis of platinum(II) and palladium(II) complexes with 9,9-dihexyl-4,5-diazafluorene and their in vivo antitumour activity against Hep3B xenografted mice

Q. W. Wang, P. L. Lam, R. S.M. Wong, G. Y.M. Cheng, K. H. Lam, Z. X. Bian, Cheuk Lam Ho, Y. H. Feng, R. Gambari, Y. H. Lo, Wai Yeung Wong, C. H. Chui

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)

Abstract

Pt-DHF- and Pd-DHF-treated groups showed significant tumour growth inhibition (with about 9-fold and 3-fold tumour growth retardation) when compared with the vehicle control group. The liver toxicology effects on the animals of the two compounds were investigated. Pt-DHF and Pd-DHF-treated groups had a lower alanine transaminase and aspartate transaminase values than those of the vehicle treated group as the animals from the vehicle control group had very heavy hepatoma burden. We assume that both complexes could be further investigated as effective antitumour agents and it is worthwhile to study their underlying working mechanism.
Original languageEnglish
Pages (from-to)537-543
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Volume124
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Antitumour
  • In vivo
  • Palladium-diazafluorene complex
  • Platinum-diazafluorene complex

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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