Abstract
Pt-DHF- and Pd-DHF-treated groups showed significant tumour growth inhibition (with about 9-fold and 3-fold tumour growth retardation) when compared with the vehicle control group. The liver toxicology effects on the animals of the two compounds were investigated. Pt-DHF and Pd-DHF-treated groups had a lower alanine transaminase and aspartate transaminase values than those of the vehicle treated group as the animals from the vehicle control group had very heavy hepatoma burden. We assume that both complexes could be further investigated as effective antitumour agents and it is worthwhile to study their underlying working mechanism.
Original language | English |
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Pages (from-to) | 537-543 |
Number of pages | 7 |
Journal | European Journal of Medicinal Chemistry |
Volume | 124 |
DOIs | |
Publication status | Published - 1 Jan 2016 |
Keywords
- Antitumour
- In vivo
- Palladium-diazafluorene complex
- Platinum-diazafluorene complex
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
- Organic Chemistry