Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging

Jing Zhu, Tianxun Gong, Atcha Kopwitthaya, Rui Hu, Wing Cheung Law, Indrajit Roy, Huijie Huang, Ken Tye Yong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

7 Citations (Scopus)

Abstract

In this contribution, we show that Au NRs functionalized with PEG molecules can be used as absorption nanoprobes for near-infrared imaging in live animals. We have found that the contrast signal of the in vivo image is dependent upon the transmission ability of the NIR light interacting with the different aspect ratios of Au NRs. Our study was focused on absorption in vivo imaging at 700 nm, which is within the transmission window of the skin. NIR absorption in vivo imaging was carried out by subcutaneous injection of mice with PEGylated Au NRs that have a LSPR around 700 nm. The formulation showed strong contrast signals under the tissues upon irradiation with NIR light. More importantly, our theoretical calculation suggested that the high contrast signals from the PEGylated Au NRs were generated via the NIR light absorption of the Au NRs within the tissue.
Original languageEnglish
Pages (from-to)12280-12286
Number of pages7
JournalRSC Advances
Volume3
Issue number30
DOIs
Publication statusPublished - 14 Aug 2013

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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