Synthesis of N,N-dimethyl-2-amino-1,2-dicyclohexylethanol and its application in the enantioselective conjugate addition of diethylzinc to enones: A convenient upgrade of the chiral ligand via hydrogenation

Pui Erh Tong, Pei Li, Albert S.C. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

17 Citations (Scopus)

Abstract

The effectiveness of N,N-dimethyl-2-amino-1,2-diphenylethanol as a chiral ligand was significantly improved via simple hydrogenation of the phenyl rings. Both the catalytic activity and the enantioselectivity of the resulting new ligand in the asymmetric conjugate addition of diethylzinc to enones were found to be superior to the original phenyl analog.
Original languageEnglish
Pages (from-to)2301-2304
Number of pages4
JournalTetrahedron Asymmetry
Volume12
Issue number16
DOIs
Publication statusPublished - 13 Sep 2001

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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