Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Ping Liu; Gui Ling Tian; Wai Hung Lo; Kin Sing Lee; Yun Hua Ye

doi:10.1081/PB-120013159

Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Ping Liu
, Gui Ling Tian
, Wai Hung Lo
, Kin Sing Lee
, Yun Hua Ye

Research output: Journal article publication › Journal article › Academic research › peer-review

9 Citations (Scopus)

Abstract

A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.

Original language	English
Pages (from-to)	29-37
Number of pages	9
Journal	Preparative Biochemistry and Biotechnology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1081/PB-120013159
Publication status	Published - 6 Apr 2002

ASJC Scopus subject areas

Biotechnology
Biochemistry

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10.1081/PB-120013159

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abstract = "A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.",

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AU - Liu, Ping

AU - Tian, Gui Ling

AU - Lo, Wai Hung

AU - Lee, Kin Sing

AU - Ye, Yun Hua

PY - 2002/4/6

Y1 - 2002/4/6

N2 - A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.

AB - A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.

UR - https://www.scopus.com/pages/publications/0036006184

U2 - 10.1081/PB-120013159

DO - 10.1081/PB-120013159

M3 - Journal article

C2 - 11934075

SN - 1082-6068

VL - 32

SP - 29

EP - 37

JO - Preparative Biochemistry and Biotechnology

JF - Preparative Biochemistry and Biotechnology

IS - 1

ER -

Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Abstract

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