Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Ping Liu, Gui Ling Tian, Wai Hung Lo, Kin Sing Lee, Yun Hua Ye

Research output: Journal article publicationJournal articleAcademic researchpeer-review

9 Citations (Scopus)

Abstract

A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.
Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalPreparative Biochemistry and Biotechnology
Volume32
Issue number1
DOIs
Publication statusPublished - 6 Apr 2002

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry

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