Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Ping Liu; Gui Ling Tian; Wai Hung Lo; Kin Sing Lee; Yun Hua Ye

doi:10.1081/PB-120013159

Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Ping Liu, Gui Ling Tian, Wai Hung Lo, Kin Sing Lee, Yun Hua Ye

Research output: Journal article publication › Journal article › Academic research › peer-review

9 Citations (Scopus)

Abstract

A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.

Original language	English
Pages (from-to)	29-37
Number of pages	9
Journal	Preparative Biochemistry and Biotechnology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1081/PB-120013159
Publication status	Published - 6 Apr 2002

ASJC Scopus subject areas

Biotechnology
Biochemistry

More information

10.1081/PB-120013159

Cite this

@article{66a11fd5774f434e80a8e34c216daa66,

title = "Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents",

abstract = "A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.",

author = "Ping Liu and Tian, {Gui Ling} and Lo, {Wai Hung} and Lee, {Kin Sing} and Ye, {Yun Hua}",

year = "2002",

month = apr,

day = "6",

doi = "10.1081/PB-120013159",

language = "English",

volume = "32",

pages = "29--37",

journal = "Preparative Biochemistry and Biotechnology",

issn = "1082-6068",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

TY - JOUR

T1 - Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

AU - Liu, Ping

AU - Tian, Gui Ling

AU - Lo, Wai Hung

AU - Lee, Kin Sing

AU - Ye, Yun Hua

PY - 2002/4/6

Y1 - 2002/4/6

N2 - A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.

AB - A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.

UR - http://www.scopus.com/inward/record.url?scp=0036006184&partnerID=8YFLogxK

U2 - 10.1081/PB-120013159

DO - 10.1081/PB-120013159

M3 - Journal article

C2 - 11934075

VL - 32

SP - 29

EP - 37

JO - Preparative Biochemistry and Biotechnology

JF - Preparative Biochemistry and Biotechnology

SN - 1082-6068

IS - 1

ER -

Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Abstract

ASJC Scopus subject areas

More information

Other files and links

Cite this