Abstract
A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.
Original language | English |
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Pages (from-to) | 29-37 |
Number of pages | 9 |
Journal | Preparative Biochemistry and Biotechnology |
Volume | 32 |
Issue number | 1 |
DOIs | |
Publication status | Published - 6 Apr 2002 |
ASJC Scopus subject areas
- Biotechnology
- Biochemistry