Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Ping Liu; Gui Ling Tian; Wai Hung Lo; Kin Sing Lee; Yun Hua Ye

doi:10.1081/PB-120013159

Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Ping Liu, Gui Ling Tian, Wai Hung Lo, Kin Sing Lee, Yun Hua Ye

Research output: Journal article publication › Journal article › Academic research › peer-review

9 Citations (Scopus)

Abstract

A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.

Original language	English
Pages (from-to)	29-37
Number of pages	9
Journal	Preparative Biochemistry and Biotechnology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1081/PB-120013159
Publication status	Published - 6 Apr 2002

ASJC Scopus subject areas

Biotechnology
Biochemistry

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10.1081/PB-120013159

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abstract = "A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.",

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AU - Lee, Kin Sing

AU - Ye, Yun Hua

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AB - A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.

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Synthesis of N-protected peptide alcohols catalyzed by subtilisin or α-chymotrypsin in organic solvents

Abstract

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