Synthesis of dual stimuli-responsive amphiphilic particles through controlled semi-batch emulsion polymerization

Chun Ho Yam, Cheng Hao Lee, Yuen Shan Siu, Kin Man Ho, Pei Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

5 Citations (Scopus)


This novel type of multicomponent polymer (MCP) particles were prepared through a one-pot controlled semi-batch emulsion polymerization which involved an initial formation of PNIPAm/PEI core-shell nanogel particle via a graft copolymerization of N-isopropyl acrylamide from PEI, followed by the seeded emulsion polymerization of methyl methacrylate or styrene. Properties of these MCP particles including particle composition, size, size distribution, surface charge and morphology were systematically examined. The structure of hydrophobic monomer was found to strongly influence the morphology of resultant MCP particles. The multilayered polystyrene/PNIPAm/PEI particles exhibited unique property of temperature-tunable surface charge. This property was demonstrated through studies of intracellular uptake of FITC-label PS/PNIPAm/PEI nanoparticles into HeLa cells at 27 and 37 °C. The results provide some insights into the design of future stimulus-responsive nanoparticle-based therapeutics.
Original languageEnglish
Pages (from-to)294-302
Number of pages9
JournalPolymer (United Kingdom)
Publication statusPublished - 5 Dec 2016


  • Amphiphilic
  • Cellular uptake
  • Multicomponent
  • Polyethyleneimine
  • Temperature-responsive

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

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