Synthesis of (±)-5′-methoxyhydnocarpin-D, an inhibitor of the Staphylococcus aureus multidrug resistance pump

Kin Fai Chan; Yunzhe Zhao; Ming Cheung Chow; Tak Hang Chan

doi:10.1016/j.tet.2005.02.024

Synthesis of (±)-5′-methoxyhydnocarpin-D, an inhibitor of the Staphylococcus aureus multidrug resistance pump

Kin Fai Chan
, Yunzhe Zhao
, Ming Cheung Chow
, Tak Hang Chan

Research output: Journal article publication › Journal article › Academic research › peer-review

11 Citations (Scopus)

Abstract

The total synthesis of regioisomerically pure (±)-5′- methoxyhydnocarpin-D (6) from commercially available vanillin (7), methyl gallate (9) and 2′,4′,6′-trihydroxyaceophenone (10) is achieved.

Original language	English
Pages (from-to)	4149-4156
Number of pages	8
Journal	Tetrahedron
Volume	61
Issue number	16
DOIs	https://doi.org/10.1016/j.tet.2005.02.024
Publication status	Published - 18 Apr 2005

Keywords

5′- Methoxyhydnocarpin-D
Mitsunobu reaction
Multidrug resistance
NorA
Staphylococcus aureus

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

More information

10.1016/j.tet.2005.02.024

Cite this

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title = "Synthesis of (±)-5′-methoxyhydnocarpin-D, an inhibitor of the Staphylococcus aureus multidrug resistance pump",

abstract = "The total synthesis of regioisomerically pure (±)-5′- methoxyhydnocarpin-D (6) from commercially available vanillin (7), methyl gallate (9) and 2′,4′,6′-trihydroxyaceophenone (10) is achieved.",

keywords = "5′- Methoxyhydnocarpin-D, Mitsunobu reaction, Multidrug resistance, NorA, Staphylococcus aureus",

author = "Chan, \{Kin Fai\} and Yunzhe Zhao and Chow, \{Ming Cheung\} and Chan, \{Tak Hang\}",

year = "2005",

month = apr,

day = "18",

doi = "10.1016/j.tet.2005.02.024",

language = "English",

volume = "61",

pages = "4149--4156",

journal = "Tetrahedron",

issn = "0040-4020",

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number = "16",

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T1 - Synthesis of (±)-5′-methoxyhydnocarpin-D, an inhibitor of the Staphylococcus aureus multidrug resistance pump

AU - Chan, Kin Fai

AU - Zhao, Yunzhe

AU - Chow, Ming Cheung

AU - Chan, Tak Hang

PY - 2005/4/18

Y1 - 2005/4/18

N2 - The total synthesis of regioisomerically pure (±)-5′- methoxyhydnocarpin-D (6) from commercially available vanillin (7), methyl gallate (9) and 2′,4′,6′-trihydroxyaceophenone (10) is achieved.

AB - The total synthesis of regioisomerically pure (±)-5′- methoxyhydnocarpin-D (6) from commercially available vanillin (7), methyl gallate (9) and 2′,4′,6′-trihydroxyaceophenone (10) is achieved.

KW - 5′- Methoxyhydnocarpin-D

KW - Mitsunobu reaction

KW - Multidrug resistance

KW - NorA

KW - Staphylococcus aureus

UR - https://www.scopus.com/pages/publications/19344364524

U2 - 10.1016/j.tet.2005.02.024

DO - 10.1016/j.tet.2005.02.024

M3 - Journal article

SN - 0040-4020

VL - 61

SP - 4149

EP - 4156

JO - Tetrahedron

JF - Tetrahedron

IS - 16

ER -

Synthesis of (±)-5′-methoxyhydnocarpin-D, an inhibitor of the Staphylococcus aureus multidrug resistance pump

Abstract

Keywords

ASJC Scopus subject areas

More information

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