Synthesis of (±)-5′-methoxyhydnocarpin-D, an inhibitor of the Staphylococcus aureus multidrug resistance pump

Kin Fai Chan, Yunzhe Zhao, Ming Cheung Chow, Tak Hang Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

The total synthesis of regioisomerically pure (±)-5′- methoxyhydnocarpin-D (6) from commercially available vanillin (7), methyl gallate (9) and 2′,4′,6′-trihydroxyaceophenone (10) is achieved.
Original languageEnglish
Pages (from-to)4149-4156
Number of pages8
JournalTetrahedron
Volume61
Issue number16
DOIs
Publication statusPublished - 18 Apr 2005

Keywords

  • 5′- Methoxyhydnocarpin-D
  • Mitsunobu reaction
  • Multidrug resistance
  • NorA
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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