Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Kai Wang; Chun Ting Poon; Wai Kwok Wong; Wai Yeung Wong; Chun Y. Choi; Daniel W.J. Kwong; Heng Zhang; Zao Ying Li

doi:10.1002/ejic.200801047

Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Kai Wang
, Chun Ting Poon
, Wai Kwok Wong
, Wai Yeung Wong
, Chun Y. Choi
, Daniel W.J. Kwong
, Heng Zhang
, Zao Ying Li

Research output: Journal article publication › Journal article › Academic research › peer-review

29 Citations (Scopus)

Abstract

A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.

Original language	English
Pages (from-to)	922-928
Number of pages	7
Journal	European Journal of Inorganic Chemistry
Issue number	7
DOIs	https://doi.org/10.1002/ejic.200801047
Publication status	Published - 1 Mar 2009
Externally published	Yes

Keywords

DNA cleavage
Photochemistry
Porphyrinoids
Sensitizers
Singlet oxygen

ASJC Scopus subject areas

Inorganic Chemistry

More information

10.1002/ejic.200801047

Cite this

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title = "Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins",

abstract = "A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.",

keywords = "DNA cleavage, Photochemistry, Porphyrinoids, Sensitizers, Singlet oxygen",

author = "Kai Wang and Poon, \{Chun Ting\} and Wong, \{Wai Kwok\} and Wong, \{Wai Yeung\} and Choi, \{Chun Y.\} and Kwong, \{Daniel W.J.\} and Heng Zhang and Li, \{Zao Ying\}",

year = "2009",

month = mar,

day = "1",

doi = "10.1002/ejic.200801047",

language = "English",

pages = "922--928",

journal = "European Journal of Inorganic Chemistry",

issn = "1434-1948",

publisher = "Wiley-VCH Verlag",

number = "7",

}

Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins. / Wang, Kai; Poon, Chun Ting; Wong, Wai Kwok et al.
In: European Journal of Inorganic Chemistry, No. 7, 01.03.2009, p. 922-928.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

AU - Wang, Kai

AU - Poon, Chun Ting

AU - Wong, Wai Kwok

AU - Wong, Wai Yeung

AU - Choi, Chun Y.

AU - Kwong, Daniel W.J.

AU - Zhang, Heng

AU - Li, Zao Ying

PY - 2009/3/1

Y1 - 2009/3/1

N2 - A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.

AB - A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.

KW - DNA cleavage

KW - Photochemistry

KW - Porphyrinoids

KW - Sensitizers

KW - Singlet oxygen

UR - https://www.scopus.com/pages/publications/61849172877

U2 - 10.1002/ejic.200801047

DO - 10.1002/ejic.200801047

M3 - Journal article

SN - 1434-1948

SP - 922

EP - 928

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 7

ER -

Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Abstract

Keywords

ASJC Scopus subject areas

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