A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.
|Number of pages||7|
|Journal||European Journal of Inorganic Chemistry|
|Publication status||Published - 1 Mar 2009|
- DNA cleavage
- Singlet oxygen
ASJC Scopus subject areas
- Inorganic Chemistry