Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Kai Wang, Chun Ting Poon, Wai Kwok Wong, Wai Yeung Wong, Chun Y. Choi, Daniel W.J. Kwong, Heng Zhang, Zao Ying Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

29 Citations (Scopus)

Abstract

A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.
Original languageEnglish
Pages (from-to)922-928
Number of pages7
JournalEuropean Journal of Inorganic Chemistry
Issue number7
DOIs
Publication statusPublished - 1 Mar 2009
Externally publishedYes

Keywords

  • DNA cleavage
  • Photochemistry
  • Porphyrinoids
  • Sensitizers
  • Singlet oxygen

ASJC Scopus subject areas

  • Inorganic Chemistry

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