Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Kai Wang; Chun Ting Poon; Wai Kwok Wong; Wai Yeung Wong; Chun Y. Choi; Daniel W.J. Kwong; Heng Zhang; Zao Ying Li

doi:10.1002/ejic.200801047

Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Kai Wang, Chun Ting Poon, Wai Kwok Wong, Wai Yeung Wong, Chun Y. Choi, Daniel W.J. Kwong, Heng Zhang, Zao Ying Li

Research output: Journal article publication › Journal article › Academic research › peer-review

29 Citations (Scopus)

Abstract

A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.

Original language	English
Pages (from-to)	922-928
Number of pages	7
Journal	European Journal of Inorganic Chemistry
Issue number	7
DOIs	https://doi.org/10.1002/ejic.200801047
Publication status	Published - 1 Mar 2009
Externally published	Yes

Keywords

DNA cleavage
Photochemistry
Porphyrinoids
Sensitizers
Singlet oxygen

ASJC Scopus subject areas

Inorganic Chemistry

More information

10.1002/ejic.200801047

Cite this

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title = "Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins",

abstract = "A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.",

keywords = "DNA cleavage, Photochemistry, Porphyrinoids, Sensitizers, Singlet oxygen",

author = "Kai Wang and Poon, {Chun Ting} and Wong, {Wai Kwok} and Wong, {Wai Yeung} and Choi, {Chun Y.} and Kwong, {Daniel W.J.} and Heng Zhang and Li, {Zao Ying}",

year = "2009",

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day = "1",

doi = "10.1002/ejic.200801047",

language = "English",

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journal = "European Journal of Inorganic Chemistry",

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publisher = "Wiley-VCH Verlag",

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Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins. / Wang, Kai; Poon, Chun Ting; Wong, Wai Kwok et al.
In: European Journal of Inorganic Chemistry, No. 7, 01.03.2009, p. 922-928.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

AU - Wang, Kai

AU - Poon, Chun Ting

AU - Wong, Wai Kwok

AU - Wong, Wai Yeung

AU - Choi, Chun Y.

AU - Kwong, Daniel W.J.

AU - Zhang, Heng

AU - Li, Zao Ying

PY - 2009/3/1

Y1 - 2009/3/1

N2 - A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.

AB - A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. KGaA.

KW - DNA cleavage

KW - Photochemistry

KW - Porphyrinoids

KW - Sensitizers

KW - Singlet oxygen

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U2 - 10.1002/ejic.200801047

DO - 10.1002/ejic.200801047

M3 - Journal article

SN - 1434-1948

SP - 922

EP - 928

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 7

ER -

Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Abstract

Keywords

ASJC Scopus subject areas

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