Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules

Shuk Yan Cheng, Marcus Chun Wah Yuen, Pik Ling Lam, Roberto Gambari, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Paul Bo San Lai, See Wai Tong, Kit Wah Chan, Fung Yi Lau, Stanton Hon Lung Kok, Kim Hung Lam, Chung Hin Chui

Research output: Journal article publicationJournal articleAcademic researchpeer-review

20 Citations (Scopus)

Abstract

The use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography-mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs.

Original languageEnglish
Pages (from-to)4147-4151
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number14
DOIs
Publication statusPublished - 15 Jul 2010

Keywords

  • Celecoxib
  • Chitosan
  • Cyclooxygenase 2
  • Oral administration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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