Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules

Shuk Yan Cheng; Marcus Chun Wah Yuen; Pik Ling Lam; Roberto Gambari; Raymond Siu Ming Wong; Gregory Yin Ming Cheng; Paul Bo San Lai; See Wai Tong; Kit Wah Chan; Fung Yi Lau; Stanton Hon Lung Kok; Kim Hung Lam; Chung Hin Chui

doi:10.1016/j.bmcl.2010.05.054

Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules

Shuk Yan Cheng, Marcus Chun Wah Yuen, Pik Ling Lam, Roberto Gambari, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Paul Bo San Lai, See Wai Tong, Kit Wah Chan, Fung Yi Lau, Stanton Hon Lung Kok, Kim Hung Lam, Chung Hin Chui

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

21 Citations (Scopus)

Abstract

The use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography-mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs.

Original language	English
Pages (from-to)	4147-4151
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2010.05.054
Publication status	Published - 15 Jul 2010

Keywords

Celecoxib
Chitosan
Cyclooxygenase 2
Oral administration

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

More information

10.1016/j.bmcl.2010.05.054

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Cheng, S. Y., Yuen, M. C. W., Lam, P. L., Gambari, R., Wong, R. S. M., Cheng, G. Y. M., Lai, P. B. S., Tong, S. W., Chan, K. W., Lau, F. Y., Kok, S. H. L., Lam, K. H., & Chui, C. H. (2010). Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules. Bioorganic and Medicinal Chemistry Letters, 20(14), 4147-4151. https://doi.org/10.1016/j.bmcl.2010.05.054

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abstract = "The use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography-mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs.",

keywords = "Celecoxib, Chitosan, Cyclooxygenase 2, Oral administration",

author = "Cheng, {Shuk Yan} and Yuen, {Marcus Chun Wah} and Lam, {Pik Ling} and Roberto Gambari and Wong, {Raymond Siu Ming} and Cheng, {Gregory Yin Ming} and Lai, {Paul Bo San} and Tong, {See Wai} and Chan, {Kit Wah} and Lau, {Fung Yi} and Kok, {Stanton Hon Lung} and Lam, {Kim Hung} and Chui, {Chung Hin}",

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doi = "10.1016/j.bmcl.2010.05.054",

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Cheng, SY, Yuen, MCW, Lam, PL, Gambari, R, Wong, RSM, Cheng, GYM, Lai, PBS, Tong, SW, Chan, KW, Lau, FY, Kok, SHL, Lam, KH & Chui, CH 2010, 'Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules', Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 14, pp. 4147-4151. https://doi.org/10.1016/j.bmcl.2010.05.054

Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules. / Cheng, Shuk Yan; Yuen, Marcus Chun Wah; Lam, Pik Ling et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 14, 15.07.2010, p. 4147-4151.

Research output: Journal article publication › Journal article › Academic research › peer-review

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AU - Cheng, Shuk Yan

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AU - Lam, Pik Ling

AU - Gambari, Roberto

AU - Wong, Raymond Siu Ming

AU - Cheng, Gregory Yin Ming

AU - Lai, Paul Bo San

AU - Tong, See Wai

AU - Chan, Kit Wah

AU - Lau, Fung Yi

AU - Kok, Stanton Hon Lung

AU - Lam, Kim Hung

AU - Chui, Chung Hin

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AB - The use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography-mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs.

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Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules

Abstract

Keywords

ASJC Scopus subject areas

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