Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells

Stanton Hon Lung Kok; Chung Hin Chui; Wing Sze Lam; Jien Chen; Fung Yi Lau; Raymond Siu Ming Wong; Gregory Yin Ming Cheng; Paul Bo San Lai; Thomas Wai Tong Leung; Michael Wing Yiu Yu; Cheuk On Tang; Albert Sun Chi Chan

doi:10.1016/j.bmcl.2006.12.039

Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells

Stanton Hon Lung Kok, Chung Hin Chui, Wing Sze Lam, Jien Chen, Fung Yi Lau, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Paul Bo San Lai, Thomas Wai Tong Leung, Michael Wing Yiu Yu, Cheuk On Tang, Albert Sun Chi Chan

Research output: Journal article publication › Journal article › Academic research › peer-review

43 Citations (Scopus)

Abstract

A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.

Original language	English
Pages (from-to)	1155-1159
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2006.12.039
Publication status	Published - 1 Mar 2007

Keywords

2-Aminobenzothiazole
Cantharimide
Neoplasm

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

More information

10.1016/j.bmcl.2006.12.039

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Kok, S. H. L., Chui, C. H., Lam, W. S., Chen, J., Lau, F. Y., Wong, R. S. M., Cheng, G. Y. M., Lai, P. B. S., Leung, T. W. T., Yu, M. W. Y., Tang, C. O., & Chan, A. S. C. (2007). Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells. Bioorganic and Medicinal Chemistry Letters, 17(5), 1155-1159. https://doi.org/10.1016/j.bmcl.2006.12.039

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abstract = "A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.",

keywords = "2-Aminobenzothiazole, Cantharimide, Neoplasm",

author = "Kok, \{Stanton Hon Lung\} and Chui, \{Chung Hin\} and Lam, \{Wing Sze\} and Jien Chen and Lau, \{Fung Yi\} and Wong, \{Raymond Siu Ming\} and Cheng, \{Gregory Yin Ming\} and Lai, \{Paul Bo San\} and Leung, \{Thomas Wai Tong\} and Yu, \{Michael Wing Yiu\} and Tang, \{Cheuk On\} and Chan, \{Albert Sun Chi\}",

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AU - Kok, Stanton Hon Lung

AU - Chui, Chung Hin

AU - Lam, Wing Sze

AU - Chen, Jien

AU - Lau, Fung Yi

AU - Wong, Raymond Siu Ming

AU - Cheng, Gregory Yin Ming

AU - Lai, Paul Bo San

AU - Leung, Thomas Wai Tong

AU - Yu, Michael Wing Yiu

AU - Tang, Cheuk On

AU - Chan, Albert Sun Chi

PY - 2007/3/1

Y1 - 2007/3/1

N2 - A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.

AB - A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.

KW - 2-Aminobenzothiazole

KW - Cantharimide

KW - Neoplasm

UR - https://www.scopus.com/pages/publications/33846994393

U2 - 10.1016/j.bmcl.2006.12.039

DO - 10.1016/j.bmcl.2006.12.039

M3 - Journal article

C2 - 17240140

SN - 0960-894X

VL - 17

SP - 1155

EP - 1159

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 5

ER -

Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells

Abstract

Keywords

ASJC Scopus subject areas

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