Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells

Stanton Hon Lung Kok; Chung Hin Chui; Wing Sze Lam; Jien Chen; Fung Yi Lau; Raymond Siu Ming Wong; Gregory Yin Ming Cheng; Paul Bo San Lai; Thomas Wai Tong Leung; Michael Wing Yiu Yu; Cheuk On Tang; Albert Sun Chi Chan

doi:10.1016/j.bmcl.2006.12.039

Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells

Stanton Hon Lung Kok
, Chung Hin Chui
, Wing Sze Lam
, Jien Chen
, Fung Yi Lau
, Raymond Siu Ming Wong
, Gregory Yin Ming Cheng
, Paul Bo San Lai
, Thomas Wai Tong Leung
, Michael Wing Yiu Yu
, Cheuk On Tang
, Albert Sun Chi Chan

Research output: Journal article publication › Journal article › Academic research › peer-review

43 Citations (Scopus)

Abstract

A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.

Original language	English
Pages (from-to)	1155-1159
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2006.12.039
Publication status	Published - 1 Mar 2007

Keywords

2-Aminobenzothiazole
Cantharimide
Neoplasm

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

More information

10.1016/j.bmcl.2006.12.039

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Kok, S. H. L., Chui, C. H., Lam, W. S., Chen, J., Lau, F. Y., Wong, R. S. M., Cheng, G. Y. M., Lai, P. B. S., Leung, T. W. T., Yu, M. W. Y., Tang, C. O., & Chan, A. S. C. (2007). Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells. Bioorganic and Medicinal Chemistry Letters, 17(5), 1155-1159. https://doi.org/10.1016/j.bmcl.2006.12.039

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abstract = "A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.",

keywords = "2-Aminobenzothiazole, Cantharimide, Neoplasm",

author = "Kok, \{Stanton Hon Lung\} and Chui, \{Chung Hin\} and Lam, \{Wing Sze\} and Jien Chen and Lau, \{Fung Yi\} and Wong, \{Raymond Siu Ming\} and Cheng, \{Gregory Yin Ming\} and Lai, \{Paul Bo San\} and Leung, \{Thomas Wai Tong\} and Yu, \{Michael Wing Yiu\} and Tang, \{Cheuk On\} and Chan, \{Albert Sun Chi\}",

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AU - Kok, Stanton Hon Lung

AU - Chui, Chung Hin

AU - Lam, Wing Sze

AU - Chen, Jien

AU - Lau, Fung Yi

AU - Wong, Raymond Siu Ming

AU - Cheng, Gregory Yin Ming

AU - Lai, Paul Bo San

AU - Leung, Thomas Wai Tong

AU - Yu, Michael Wing Yiu

AU - Tang, Cheuk On

AU - Chan, Albert Sun Chi

PY - 2007/3/1

Y1 - 2007/3/1

N2 - A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.

AB - A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.

KW - 2-Aminobenzothiazole

KW - Cantharimide

KW - Neoplasm

UR - https://www.scopus.com/pages/publications/33846994393

U2 - 10.1016/j.bmcl.2006.12.039

DO - 10.1016/j.bmcl.2006.12.039

M3 - Journal article

C2 - 17240140

SN - 0960-894X

VL - 17

SP - 1155

EP - 1159

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 5

ER -

Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells

Abstract

Keywords

ASJC Scopus subject areas

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