Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation

Kang Jin; Kathy Hiu Laam Po; Shengxi Wang; Jonathan Avraham Reuven; Chi Nga Wai; Ho Ting Lau; Ting Ho Chan; Sheng Chen; Xuechen Li

doi:10.1016/j.bmc.2017.04.039

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation

Kang Jin, Kathy Hiu Laam Po, Shengxi Wang, Jonathan Avraham Reuven, Chi Nga Wai, Ho Ting Lau, Ting Ho Chan, Sheng Chen, Xuechen Li

Research output: Journal article publication › Journal article › Academic research › peer-review

39 Citations (Scopus)

Abstract

anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.

Original language	English
Pages (from-to)	4990-4995
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	25
Issue number	18
DOIs	https://doi.org/10.1016/j.bmc.2017.04.039
Publication status	Published - 1 Jan 2017

Keywords

SAR study
Ser/Thr ligation
Teixobactin analogues

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

More information

10.1016/j.bmc.2017.04.039

Cite this

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title = "Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation",

abstract = "anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.",

keywords = "SAR study, Ser/Thr ligation, Teixobactin analogues",

author = "Kang Jin and Po, {Kathy Hiu Laam} and Shengxi Wang and Reuven, {Jonathan Avraham} and Wai, {Chi Nga} and Lau, {Ho Ting} and Chan, {Ting Ho} and Sheng Chen and Xuechen Li",

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AU - Jin, Kang

AU - Po, Kathy Hiu Laam

AU - Wang, Shengxi

AU - Reuven, Jonathan Avraham

AU - Wai, Chi Nga

AU - Lau, Ho Ting

AU - Chan, Ting Ho

AU - Chen, Sheng

AU - Li, Xuechen

PY - 2017/1/1

Y1 - 2017/1/1

N2 - anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.

AB - anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.

KW - SAR study

KW - Ser/Thr ligation

KW - Teixobactin analogues

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U2 - 10.1016/j.bmc.2017.04.039

DO - 10.1016/j.bmc.2017.04.039

M3 - Journal article

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SN - 0968-0896

VL - 25

SP - 4990

EP - 4995

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 18

ER -

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation

Abstract

Keywords

ASJC Scopus subject areas

More information

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