Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation

Kang Jin, Kathy Hiu Laam Po, Shengxi Wang, Jonathan Avraham Reuven, Chi Nga Wai, Ho Ting Lau, Ting Ho Chan, Sheng Chen, Xuechen Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

27 Citations (Scopus)

Abstract

anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.
Original languageEnglish
Pages (from-to)4990-4995
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume25
Issue number18
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • SAR study
  • Ser/Thr ligation
  • Teixobactin analogues

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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