Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD

Keyphrases

• Synthetic Evaluation 100%
• Caffeic Acid 100%
• Pharmacological Evaluation 100%
• Tacrine Derivatives 100%
• Disease Pathways 100%
• Acetylcholinesterase Inhibition 50%
• Alzheimer's Disease 50%
• Tacrine 50%
• Induced Cell Death 50%
• Glutamate 50%
• Neuroprotective Effect 50%
• Low Toxicity 50%
• Amyloid Protein 50%
• β-site APP-cleaving Enzyme 1 (BACE1) 50%
• Antioxidant Capacity 50%
• Ferulic Acid 50%
• DPPH Radical Scavenging Activity 50%
• Targeting Ligands 50%
• Antioxidant Assay 50%
• HT22 Cells 50%
• Lipoic Acid 50%
• Self-aggregation 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Caffeic Acid 100%
• Tacrine Derivative 100%
• Diseases 100%
• Antioxidant Capacity 50%
• Antioxidant Study 50%
• Amyloid A Protein 50%
• Ferulic Acid 50%
• Lipoic Acid 50%
• Tacrine 50%
• Alzheimer's Disease 50%
• Neuroprotective Agent 50%
• Acetylcholinesterase 50%
• Glutamic Acid 50%

Chemistry

• Tacrine 100%
• Caffeic Acid 66%
• Neuroprotective 33%
• Antioxidant Agent 33%
• Radical Scavenger 33%
• Ferulic Acid 33%
• Antioxidant Capacity 33%
• Lipoic Acid 33%
• Glutamic Acid 33%
• Cell Death 33%