Synthesis and cytotoxicity studies of artemisinin derivatives containing lipophilic alkyl carbon chains

Yungen Liu, Vincent Kam Wai Wong, Chi Bun Ko, Man Kin Wong, Chi Ming Che

Research output: Journal article publicationJournal articleAcademic researchpeer-review

49 Citations (Scopus)

Abstract

(Chemical Equation Presented) Cytotoxic artemisinin derivatives have been synthesized by a modular approach of "artemisinin + linker + lipophilic alkyl carbon chain". A strong correlation between the length of the carbon chains and the cytotoxicities against human hepatocellular carcinoma (HepG2) was revealed. Notably, compared with artemisinin (IC50 = 97 μM), up to 200-fold more potent cytotoxicity (IC50 = 0.46 μM) could be achieved by attachment of a C14H29 carbon chain to artemisinin via an amide linker.
Original languageEnglish
Pages (from-to)1561-1564
Number of pages4
JournalOrganic Letters
Volume7
Issue number8
DOIs
Publication statusPublished - 14 Apr 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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